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Dry Film Photoresist-based Electrochemical Microfluidic Biosensor Platform: Device Fabrication, On-chip Assay Preparation, and System Operation

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Building Block Engineering toward Realizing High-Performance Electrochromic Materials and Glucose Biosensing

Aliekber Karabag^1,2, Dilek Soyler³, Yasemin Arslan Udum⁴

¹Faculty of Science, Department of Chemistry, Middle East Technical University, Ankara 06800, Turkey.

|July 28, 2023

Summary

Molecular engineering of conjugated polymers using thieno[3,4-c]pyrrole-4,6-dione (TPD) building blocks impacts optoelectronic and biosensing properties. EDOT modification enhances electrochromic performance and supercapacitor applications, while selenophene shows limitations in biosensing.

Keywords:

3,4-ethylenedioxythiophene (EDOT)Stille cross-coupling conjugated monomers optoelectronic and biosensing properties selenophene thieno[3,4-c]pyrrole-4,6-dione (TPD)

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Area of Science:

Materials Science
Polymer Chemistry
Electrochemistry

Background:

Molecular engineering of conjugated systems is key to advancing optoelectronic properties and biosensing.
Thieno[3,4-c]pyrrole-4,6-dione (TPD)-based polymers offer a versatile platform for structure-property relationship studies.
Understanding how structural modifications influence material performance is crucial for developing new functional materials.

Purpose of the Study:

To synthesize and characterize novel TPD-based conjugated monomers incorporating selenophene and 3,4-ethylenedioxythiophene (EDOT).
To investigate the electrochromic properties and potential applications of these polymers in glucose biosensing.
To systematically analyze the impact of structural variations on electrochemical, electronic, optical, and biosensing characteristics.

Main Methods:

Synthesis of three TPD-based monomers (Se-TPD, EDOT-TPD, EDOT-Se-TPD) via Stille cross-coupling.
Electrochemical polymerization of the synthesized monomers.
Systematic investigation of electrochemical, optical (UV-Vis), and electrochromic properties, alongside biosensing performance evaluation.

Main Results:

EDOT-containing polymers exhibited high charge capacity and rapid charge propagation, suitable for supercapacitors.
EDOT-modified materials showed broad absorption, low optical band gaps, superior optical contrast, fast switching, and multi-color electrochromism.
Selenophene-containing polymers demonstrated poor biosensing performance due to suboptimal biomolecule localization.

Conclusions:

Structural modifications in TPD-based donor-acceptor polymers significantly influence optoelectronic and biosensing properties.
EDOT incorporation is beneficial for electrochromic devices and supercapacitors, offering tunable optical and electrochemical characteristics.
Selenophene modification requires further optimization for effective integration into biosensing platforms.