Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Modified-Release Drug Delivery Systems: Stimuli-Activated01:30

Modified-Release Drug Delivery Systems: Stimuli-Activated

Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Infective endocarditis in Poland: Five-year clinical report (2021-2025). Insight from the POL-ENDO registry.

Kardiologia polska·2026
Same author

Color Stability of 3D-Printed Dental Resins Following Different Surface Treatments.

Polymers·2026
Same author

Bicuspid aortic valve type in predicting the occurrence of paravalvular leak following transcatheter aortic valve implantation.

Kardiologia polska·2026
Same author

Metallogels as Hybrid Metal-Organic Soft Materials: Classification, Fabrication Pathways and Functional Applications.

Gels (Basel, Switzerland)·2026
Same author

When rare entities converge: Apericardial cyst and anomalous origin of the right coronary artery from pulmonary trunk case report.

Kardiologia polska·2026
Same author

Wear Measurements in Cylindrical Telescopic Crowns Using an Active Piezoresistive Cantilever with an Integrated Gold Microsphere Probe.

Materials (Basel, Switzerland)·2025

Related Experiment Video

Updated: Jun 19, 2026

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
12:27

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Published on: August 22, 2016

7.7K

Hyaluronic Acid-Alginate Homogeneous Structures with Polylactide Coating Applied in Controlled Antibiotic Release.

Anna Trusek1, Maciej Grabowski1, Omoyemi Ajayi1

  • 1Department of Micro, Nano and Bioprocess Engineering, Wroclaw University of Science and Technology, Wybrzeze Wyspianskiego 27, 50-370 Wroclaw, Poland.

Gels (Basel, Switzerland)
|July 28, 2023
PubMed
Summary

Chemically cross-linked hyaluronic acid-alginate hydrogels coated with polylactide significantly extend drug release. This controlled-release drug delivery system enhances antibiotic efficacy for treating local infections in dentistry and wound care.

Keywords:
Korsmeyer–Peppas modelchemical hydrogel crosslinkingcore–shell carrierdental infectiondiffusion drug releasehyaluronic acid (HA)polylactide (PLA) coating

More Related Videos

Author Spotlight: Advancing Therapeutics with Biocompatible Sodium Alginate Hydrogel Microspheres
07:24

Author Spotlight: Advancing Therapeutics with Biocompatible Sodium Alginate Hydrogel Microspheres

Published on: June 7, 2024

2.0K
Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing
04:09

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing

Published on: December 13, 2024

632

Related Experiment Videos

Last Updated: Jun 19, 2026

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery
12:27

Polyelectrolyte Complex for Heparin Binding Domain Osteogenic Growth Factor Delivery

Published on: August 22, 2016

7.7K
Author Spotlight: Advancing Therapeutics with Biocompatible Sodium Alginate Hydrogel Microspheres
07:24

Author Spotlight: Advancing Therapeutics with Biocompatible Sodium Alginate Hydrogel Microspheres

Published on: June 7, 2024

2.0K
Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing
04:09

Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel FilmWound Healing

Published on: December 13, 2024

632

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Hydrogels are promising biocompatible and biodegradable drug carriers for local infections.
  • A key limitation of hydrogels is their rapid drug release rate.
  • Controlled-release systems are crucial for sustained therapeutic effects.

Purpose of the Study:

  • To develop a novel controlled-release drug carrier based on hyaluronic acid-alginate hydrogels.
  • To enhance the drug release profile of hydrogel carriers through chemical cross-linking and polymer coating.
  • To evaluate the potential of these carriers for delivering antibiotics like amoxycillin, metronidazole, and doxycycline.

Main Methods:

  • Chemically cross-linking hyaluronic acid-alginate (HA-SAL) using 1-ethyl-3-(3-dimethyl aminopropyl)-1-carbodiimide hydrochloride (EDC).
  • Coating the cross-linked HA-SAL hydrogel carriers with a polylactide polymer layer.
  • Investigating the effect of the polylactide coating on the drug release kinetics.

Main Results:

  • The polylactide coating significantly reduced the mass flux of the hydrogel carriers.
  • Drug release time was extended by approximately forty times compared to uncoated hydrogels.
  • The modified hydrogels demonstrated potential for sustained delivery of amoxycillin, metronidazole, and doxycycline.

Conclusions:

  • Chemically cross-linked HA-SAL hydrogels coated with polylactide offer a viable strategy for controlled drug release.
  • This approach effectively overcomes the rapid release limitation of traditional hydrogels.
  • The developed system shows promise for localized antibiotic delivery in dentistry and wound treatment.