Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Degenerative Disc Disease I: Introduction01:27

Degenerative Disc Disease I: Introduction

29
Degenerative disc disease is a chronic condition in which intervertebral discs gradually lose structure and function. It is not infectious or autoimmune; rather, it results from age-related biochemical and mechanical changes, influenced by genetic, metabolic, and environmental factors.Structure and Function of DiscsThe spine contains 23 intervertebral discs that absorb load, distribute forces, maintain spacing, and allow flexibility. Each disc consists of a nucleus pulposus, a gel-like core...
29
Degenerative Disc Disease ll: Pathophysiology01:23

Degenerative Disc Disease ll: Pathophysiology

30
The symptoms of degenerative disc disease arise from a combination of mechanical compression, vascular compromise, and biochemical inflammation, which together disrupt nerve function and produce pain.Mechanical CompressionDisc degeneration reduces height and elasticity, predisposing to herniation of the nucleus pulposus, a major cause of radicular pain. Herniations may be protrusion (bulging with intact annulus), extrusion (nucleus extends beyond disc but remains connected), or sequestration...
30

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Correction: ISSLS Prize in Clinical Science 2026: Data-driven classification of lumbar spine degeneration trajectories in chronic low back pain.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same author

Vertebral endplate bone marrow lesion composition: relation to Modic change classification and associations with chronic low back pain.

The spine journal : official journal of the North American Spine Society·2026
Same author

Effects of romosozumab on bone strength around a pedicle screw as evaluated by biomechanical computed tomography-based virtual stress tests in postmenopausal women.

The spine journal : official journal of the North American Spine Society·2026
Same author

ISSLS Prize in Clinical Science 2026: Data-driven classification of lumbar spine degeneration trajectories in chronic low back pain.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·2026
Same author

Femora from adults with type 1 or type 2 diabetes have lower bone strength and smaller hip geometry.

JBMR plus·2026
Same author

A Review on Osteoporosis.

JAMA·2025

Related Experiment Video

Updated: May 2, 2026

Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography
04:24

Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography

Published on: November 22, 2017

10.0K

Radiation-induced changes in load-sharing and structure-function behavior in murine lumbar vertebrae.

Tongge Wu1, Noah B Bonnheim2, Megan M Pendleton1

  • 1Department of Mechanical Engineering, University of California, Berkeley, CA, USA.

Computer Methods in Biomechanics and Biomedical Engineering
|July 28, 2023
PubMed
Summary

Ionizing radiation exposure reduced trabecular bone volume in mouse lumbar vertebrae, leading to increased reliance on the vertebral cortex for load bearing. This study reveals radiation

Keywords:
Ionizing radiationbone mechanicsfinite element analysis (FEA)micro-mechanicsstructure-function behaviorvertebral bone

More Related Videos

A Mouse Model of Lumbar Spine Instability
05:28

A Mouse Model of Lumbar Spine Instability

Published on: April 23, 2021

8.0K
Author Spotlight: Enhancing Small Animal Bone Compression Testing for Research
07:52

Author Spotlight: Enhancing Small Animal Bone Compression Testing for Research

Published on: December 1, 2023

1.8K

Related Experiment Videos

Last Updated: May 2, 2026

Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography
04:24

Proper Positioning and Restraint of a Rat Hind Limb for Focused High Resolution Imaging of Bone Micro-architecture Using In Vivo Micro-computed Tomography

Published on: November 22, 2017

10.0K
A Mouse Model of Lumbar Spine Instability
05:28

A Mouse Model of Lumbar Spine Instability

Published on: April 23, 2021

8.0K
Author Spotlight: Enhancing Small Animal Bone Compression Testing for Research
07:52

Author Spotlight: Enhancing Small Animal Bone Compression Testing for Research

Published on: December 1, 2023

1.8K

Area of Science:

  • Biomechanics
  • Radiology
  • Orthopedics

Background:

  • Ionizing radiation is used in medical treatments, but its effects on bone microstructure and mechanical function are not fully understood.
  • Understanding radiation's impact on bone is crucial for managing patient outcomes and developing protective strategies.

Purpose of the Study:

  • To investigate the biomechanical effects of ionizing radiation on murine lumbar vertebrae microstructure and mechanical function.
  • To evaluate changes in vertebral microstructure, whole-bone stiffness, and cortical-trabecular load sharing following radiation exposure.

Main Methods:

  • Micro-computed tomography (micro-CT) based finite element analysis was employed.
  • Murine lumbar vertebrae (L5) were analyzed 11 days post-exposure to a 5 Gy total dose of ionizing radiation.
  • Trabecular and cortical bone microstructure, whole-bone stiffness, and load distribution were quantified and compared between irradiated and control groups.

Main Results:

  • Irradiated vertebrae showed significantly reduced trabecular bone volume and altered microstructure (p < 0.001), while cortical bone volume remained unchanged.
  • Axial compressive loads were redistributed from the trabecular centrum to the vertebral cortex in irradiated mice, indicated by a higher cortical load-fraction (p = 0.02).
  • The structure-function relationship between trabecular bone volume and load fraction differed, suggesting a less biomechanically efficient trabecular network in irradiated vertebrae (p = 0.03).

Conclusions:

  • Ionizing radiation decreases trabecular bone volume and compromises the biomechanical efficiency of the vertebral trabecular structure.
  • Radiation exposure leads to an increased reliance on the vertebral cortex to resist compressive loads, altering the load-sharing mechanism.
  • These findings provide biomechanical insights into radiation-induced structural changes in murine lumbar vertebrae, independent of material property changes.