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Total syntheses of macleanine and lycoposerramine-S
Masahiro Okuyama1, Nariyoshi Umekubo1, Kenta Akimoto1
1Graduate School of Pharmaceutical Sciences, Nagoya University, Nagoya 464-8601, Japan. yokosima@ps.nagoya-u.ac.jp.
Organic & Biomolecular Chemistry
|July 28, 2023
Abstract:
Total syntheses of fawcettimine-class Lycopodium alkaloids having an imino bridge between C5 and C13 were accomplished. Fawcettimine was first prepared in 10 steps from a known compound, and the characteristic structures, including the imino bridge, were constructed via the formation of a bridgehead imine.
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