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Ameliorative effect of mussel-derived ACE inhibitory peptides on spontaneous hypertension rats

Qiaoni You1, Xiaopeng Sun1, Jinli Chen2

  • 1College of Life Sciences, Qingdao University, 308 Ningxia Road, Qingdao, 266071, China.

European Journal of Nutrition
|July 28, 2023
PubMed
Abstract

Insights

Novel mussel-derived peptides (MEPs) show stable angiotensin-converting enzyme (ACE) inhibitory activity and effectively lower blood pressure in hypertensive rats. These findings suggest MEPs

Area of Science:

  • Biotechnology
  • Food Science
  • Pharmacology

Background:

  • Hypertension is a major global health concern.
  • Angiotensin-converting enzyme (ACE) plays a key role in blood pressure regulation.
  • Natural sources are being explored for antihypertensive compounds.

Purpose of the Study:

  • To prepare novel mussel-derived ACE inhibitory peptides (MEPs).
  • To investigate the in vivo antihypertensive effects of MEPs.
  • To assess the stability and identify active peptide components.

Main Methods:

  • Enzymatic hydrolysis of Mytilus edulis to obtain MEPs.
  • In vitro stability assessment (heat, pH, ions, digestion).
  • In vivo antihypertensive study in spontaneously hypertensive rats (SHRs).
  • Purification and identification using chromatography and LC-MS/MS.

Main Results:

  • MEPs exhibited stability under various conditions.
  • MEPs significantly reduced systolic and diastolic blood pressure in SHRs.
  • MEPs modulated vascular remodeling, renin-angiotensin system (RAS), and fibrosis.
  • Five peptides were identified, with Ile-Leu-Thr-Glu-Arg showing highest ACE inhibition.

Conclusions:

  • MEPs possess significant antihypertensive properties.
  • MEPs demonstrate potential as functional food ingredients for blood pressure management.
  • Further research into MEPs' therapeutic applications is warranted.
Keywords:
ACE inhibitory peptides (MEPs)Amino acid sequenceAntihypertensive effectMytilus edulisSpontaneously hypertensive rats (SHRs)

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