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Developing Neuroimaging Phenotypes of the Default Mode Network in PTSD: Integrating the Resting State, Working Memory, and Structural Connectivity

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Neuroticism and white matter hyperintensities.

Antonio Terracciano¹, Bertin Cenatus¹, Xianghe Zhu²

¹Department of Geriatrics, Florida State University College of Medicine, Tallahassee, FL, USA.

Journal of Psychiatric Research

|July 28, 2023

Summary

High neuroticism is linked to more white matter hyperintensities, a marker of brain aging. This brain integrity measure partly explains why neuroticism affects cognitive function in older adults.

Keywords:

Cognition Leukoaraiosis Neuroticism Personality Risk factor White matter hyperintensities

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Published on: November 27, 2019

Area of Science:

Neuroscience
Psychiatry
Gerontology

Background:

Neuroticism is a significant risk factor for neurodegenerative diseases like Alzheimer's.
White matter hyperintensities (WMH) are indicators of brain integrity and linked to cognitive decline.

Purpose of the Study:

To examine the association between neuroticism and white matter hyperintensities.
To determine if white matter hyperintensities mediate the relationship between neuroticism and cognitive function.

Main Methods:

Utilized UK Biobank data from 40,602 middle-aged and older adults.
Assessed neuroticism, cognitive function, and white matter hyperintensities via MRI.
Employed regression analyses and mediation models, controlling for covariates.

Main Results:

Higher neuroticism scores correlated with increased white matter hyperintensities.
Vascular risk factors explained approximately 40% of this association.
White matter hyperintensities partially mediated the link between neuroticism and cognitive function.

Conclusions:

White matter integrity represents a neurobiological pathway linking neuroticism to cognitive health.
Findings highlight the role of brain integrity in the association between personality traits and cognitive outcomes.