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Birth and death view of DNA, RNA, and proteins

Pooja Kumari1, Neel Sarovar Bhavesh2

  • 1Amity Institute of Biotechnology, Amity University Jharkhand, Ranchi, Jharkhand 834001, India.

Gene
|July 28, 2023
PubMed

Insights

Cells precisely control gene expression through DNA replication, RNA synthesis, and turnover. This review details molecular mechanisms regulating cellular processes from development to disease.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cell Biology

Background:

  • Cellular regulation is crucial for development, homeostasis, and disease.
  • Gene expression control is fundamental to all life processes.

Purpose of the Study:

  • To review the diverse molecular mechanisms of gene regulation.
  • To highlight recent advances in understanding cellular regulatory pathways.

Main Methods:

  • Literature review of DNA replication and degradation.
  • Analysis of mRNA synthesis, processing, and export.
  • Examination of mRNA turnover pathways.
  • Overview of protein synthesis and modification.

Main Results:

  • Detailed mechanisms of DNA replication and degradation.
  • Comprehensive description of mRNA capping, splicing, tailing, and export.
  • Explanation of mRNA turnover processes like RNA interference.
  • Summary of post-translational modifications and protein turnover.

Conclusions:

  • Cellular regulation involves a complex interplay of molecular mechanisms.
  • Recent advances provide deeper insights into these intricate pathways.
Keywords:
Cellular regulationProtein turnoverReplicationTranscriptionTranslationmRNA turnover

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