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Updated: Jul 21, 2025

VisualEyes: A Modular Software System for Oculomotor Experimentation
Published on: March 25, 2011
Eyes and the heart: what a clinician should know
Jing Yong Ng1, Essa Zarook1, Luke Nicholson2,3
1Medical Education Department, Queen Mary University of London, Barts and the London School of Medicine and Dentistry, London, UK.
Insights
Ocular signs can indicate underlying cardiovascular disease. This review highlights the connection between eye conditions and systemic cardiovascular health, aiding diagnosis and management.
Area of Science:
- Ophthalmology
- Cardiology
- Systemic Diseases
Background:
- The eye can manifest signs of primary ocular or systemic diseases, including cardiovascular conditions.
- Systemic diseases like hypertension, diabetes, and autoimmune disorders have distinct ocular presentations.
- Neuromuscular and connective tissue diseases also exhibit characteristic ocular and cardiac findings.
Purpose of the Study:
- To review the intricate relationship between ocular and cardiovascular systems.
- To emphasize the diagnostic, prognostic, and management implications of this interplay.
- To explore the utility of conventional and novel diagnostic tools.
Main Methods:
- Literature review of studies examining ocular manifestations of cardiovascular diseases.
- Analysis of systemic diseases with known ocular and cardiac involvement.
- Discussion of diagnostic tools for assessing the eye-cardiovascular link.
Main Results:
- Hypertension and diabetes cause retinopathy; dyslipidemia presents with corneal arcus.
- Autoimmune diseases (Graves', rheumatoid arthritis, sarcoidosis) manifest as proptosis, episcleritis, and scleritis.
- Myasthenia gravis, Marfan syndrome, Wilson's disease, and Fabry disease show specific ocular and cardiac associations.
Conclusions:
- Ocular assessment is crucial in cardiovascular examinations.
- Recognizing ocular signs aids in early diagnosis and management of systemic and cardiovascular diseases.
- Integrating advanced diagnostic tools can improve patient outcomes.
Abstract:
The eye is prone to various forms of afflictions, either as a manifestation of primary ocular disease or part of systemic disease, including the cardiovascular system. A thorough cardiovascular examination should include a brief ocular assessment. Hypertension and diabetes, for example, would present with retinopathy and dyslipidaemia would present with corneal arcus. Multisystem autoimmune diseases, such as Graves' disease, rheumatoid arthritis and sarcoidosis, would present with proptosis, episcleritis and scleritis, respectively. Myasthenia gravis, while primarily a neuromuscular disease, presents with fatigable ptosis and is associated with Takotsubo cardiomyopathy and giant cell myocarditis. Connective tissue diseases such as Marfan syndrome, which commonly presents with aortic root dilatation, would be associated with ectopia lentis and myopia. Wilson's disease, which is associated with arrhythmias and cardiomyopathies, would present usually with the characteristic Kayser-Fleischer rings. Rarer diseases, such as Fabry disease, would be accompanied by ocular signs such as cornea verticillata and such cardiac manifestations include cardiac hypertrophy as well as arrhythmias. This review examines the interplay between the eye and the cardiovascular system and emphasises the use of conventional and emerging tools to improve diagnosis, management and prognostication of patients.
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