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Related Experiment Videos

Incidental lesions in nonhuman primate placentae.

T E Bunton

    Veterinary Pathology
    |July 1, 1986
    PubMed
    Summary

    This study examined placental lesions in rhesus macaques, finding common incidental findings like fibrin deposition and inflammation. These lesions, also seen in humans, may indicate pregnancy issues if severe.

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    Area of Science:

    • Reproductive Biology
    • Comparative Pathology
    • Primate Medicine

    Background:

    • The third trimester of pregnancy in rhesus macaques involves complex placental development.
    • Incidental placental lesions are common but their significance requires further investigation.

    Purpose of the Study:

    • To characterize incidental lesions in third-trimester rhesus macaque placentae.
    • To compare findings with human placental pathology.

    Main Methods:

    • Examination of 21 third-trimester rhesus macaque placentae.
    • Macroscopic and histologic evaluation of placental tissues.
    • Correlation of placental weight with fetal weight.

    Main Results:

    • Placentae showed common lesions including fibrin deposition, infarction, hematoma, and calcification.
    • Histologic findings included villous fibrinoid necrosis, inflammation, and vascular changes.
    • Calcification increased significantly in the entire placental tissue by term.

    Conclusions:

    • Rhesus macaque placental lesions observed are similar to those found incidentally in humans.
    • The degree of these lesions may correlate with pregnancy wastage in both species.

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