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Association between systemic inflammatory response index and left ventricular remodeling and systolic dysfunction in

Runze Chi1, Xiaoli Shan1, ChunPing Guan1

  • 1Qingdao Municipal Hospital, Qingdao University Affiliated Qingdao Municipal Hospital, 266011, Qingdao, Shandong, China.

BMC Cardiovascular Disorders
|July 28, 2023
PubMed

Insights

The systemic inflammatory response index (SIRI) is linked to cardiac remodeling and dysfunction in atrial fibrillation (AF) patients. Higher SIRI levels indicate a greater risk of impaired heart structure and function in individuals with AF.

Area of Science:

  • Cardiology
  • Inflammation Research
  • Biomarker Discovery

Background:

  • Atrial fibrillation (AF) is a common arrhythmia that can lead to cardiac remodeling and impaired systolic function.
  • Inflammation plays a crucial role in the pathophysiology of cardiovascular diseases, including AF.

Purpose of the Study:

  • To investigate the association between the systemic inflammatory response index (SIRI) and left ventricular (LV) remodeling and systolic function in patients with AF.
  • To evaluate SIRI as a potential biomarker for cardiac dysfunction in AF.

Main Methods:

  • A retrospective study included 416 patients diagnosed with AF.
  • The systemic inflammatory response index (SIRI) was calculated using the formula: neutrophil count × monocyte count / lymphocyte count.
  • Cardiac parameters, including LV dimensions, mass, ejection fraction, and left atrial (LA) diameter, were assessed.

Main Results:

  • SIRI showed significant correlations with multiple cardiac parameters, including LV end-diastolic diameter, LV posterior wall thickness, interventricular septal thickness, LV mass index (LVMI), LV ejection fraction (LVEF), and LA diameter (LAD).
  • Multivariate analyses revealed SIRI's significant association with LVMI, LVEF, and LAD.
  • The highest quartile of SIRI was significantly linked to LV hypertrophy, impaired LV systolic function, and LA enlargement.

Conclusions:

  • The systemic inflammatory response index (SIRI) is significantly associated with left ventricular remodeling and systolic function impairment in patients with atrial fibrillation.
  • SIRI may serve as a practical and dependable inflammatory biomarker for identifying cardiac structural and functional abnormalities in individuals with AF.
Abstract

Keywords:
Atrial fibrillationLeft ventricular remodelingLeft ventricular systolic dysfunctionSystemic inflammatory response index

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