Related Experiment Video

Updated: Jul 21, 2025

Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe
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Analyzing Oxidative Stress in Murine Intestinal Organoids using Reactive Oxygen Species-Sensitive Fluorogenic Probe

Published on: September 17, 2021

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Roles of Oxidative Stress and Nrf2 Signaling in Pathogenic and Non-Pathogenic Cells: A Possible General Mechanism of

Mira Hammad1, Mohammad Raftari2, Rute Cesário2

  • 1University of Caen Normandy, UMR6252 CIMAP/ARIA, GANIL, 14000 Caen, France.

Antioxidants (Basel, Switzerland)
|July 29, 2023
PubMed

Insights

Nuclear factor erythroid-2-related factor 2 (Nrf2) is a key regulator of cellular defense, controlling antioxidant systems and cell fate. Its dysregulation links to diseases and impaired immune responses, highlighting its critical role in health and infection.

Area of Science:

  • Cellular Biology
  • Molecular Biology
  • Immunology

Background:

  • Nuclear factor erythroid-2-related factor 2 (Nrf2) is a master regulator of the cellular antioxidant system.
  • Nrf2 influences multiple pathways, including redox homeostasis, xenobiotics, and iron metabolism.
  • Dysregulation of Nrf2 signaling is implicated in cancer, infectious diseases, and aging.

Purpose of the Study:

  • To review the multifaceted role of Nrf2 in cellular functions.
  • To elucidate Nrf2's involvement in both non-pathogenic and pathogenic cellular processes.
  • To highlight the impact of Nrf2 on immune response and disease susceptibility.

Main Methods:

  • Literature review of Nrf2's functions.
  • Analysis of Nrf2's role in various signaling pathways.
  • Examination of Nrf2's impact on cellular fate and disease.

Main Results:

  • Nrf2 controls cell proliferation, differentiation, apoptosis, therapy resistance, and senescence.
  • Nrf2 dysregulation is linked to carcinogenic phenomena and age-related diseases.
  • Impaired Nrf2 function can compromise oxidative burst, increasing susceptibility to infections.

Conclusions:

  • Nrf2 is a critical coordinator of cellular defense mechanisms.
  • Understanding Nrf2's complex regulatory networks is essential for addressing disease.
  • Further research is needed to fully elucidate the molecular mechanisms of Nrf2 signaling.
Keywords:
ROS: Nrf2 signalingadipogenesiscancercancer stem cellinfection diseasesmalariaosteogenesisoxidative stressstem cell differentiationtreatment resistance

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