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Related Experiment Video

Updated: Jul 21, 2025

Author Spotlight: High-Resolution 4D Light-Sheet Imaging and Virtual Reality in Zebrafish for Single-Cell Analysis of Heart Function
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Information-Rich Multi-Functional OCT for Adult Zebrafish Intra- and Extracranial Imaging.

Di Yang1, Weike Wang1, Zhuoqun Yuan1

  • 1Tianjin Key Laboratory of Micro-Scale Optical Information Science and Technology, Institute of Modern Optics, Nankai University, Tianjin 300350, China.

Bioengineering (Basel, Switzerland)
|July 29, 2023
PubMed
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High-resolution optical coherence tomography (OCT) provides novel insights into zebrafish brain and skull research. This advanced imaging technique reveals detailed intra- and extracranial information, including previously unobserved cranial suture channels.

Area of Science:

  • Neuroscience and Developmental Biology
  • Biomedical Imaging and Optics

Background:

  • Zebrafish are a key animal model for intra- and extracranial research, including brain and skull studies.
  • Effective in vivo imaging is crucial for understanding adult zebrafish development and regeneration.
  • A versatile imaging technique is needed to visualize both intra- and extracranial conditions simultaneously.

Purpose of the Study:

  • To employ a high-resolution, multi-functional optical coherence tomography (OCT) system for adult zebrafish imaging.
  • To obtain comprehensive intra- and extracranial imaging data for biological and pathological studies.
  • To investigate novel anatomical structures and their potential functions within the zebrafish skull.

Main Methods:

  • Utilized a high-resolution, multi-functional optical coherence tomography (OCT) system.
Keywords:
cranial imagingoptical coherence tomography (OCT)optical coherence tomography angiography (OCTA)polarization-sensitive optical coherence tomography (PS-OCT)zebrafish

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  • Acquired detailed intra- and extracranial images of adult zebrafish.
  • Analyzed imaging data for pigmentation, tissue characteristics, vascular networks, and traumatic brain injury (TBI) effects.

    • Main Results:

    • Achieved rich intra- and extracranial imaging outcomes, including pigmentation distribution and tissue-specific details.
    • Successfully visualized cranial vasculature and monitored traumatic brain injury (TBI) in adult zebrafish.
    • First observation of channels through zebrafish cranial sutures, suggesting a role in maintaining suture patency.

    Conclusions:

    • A high-resolution, multi-functional OCT system offers extensive novel biological information for zebrafish research.
    • This imaging approach is valuable for both intra- and extracranial studies, advancing our understanding of zebrafish biology.
    • The discovery of cranial suture channels opens new avenues for research into skull development and integrity.