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Multifunctional Sodium Hyaluronate/Chitosan Foam Used as an Absorbable Hemostatic Material
Ran Chen1, Fanglin Du2, Qipeng Yuan1
1Laboratory of Biosynthesis and Efficient Separation of Natural Active Ingrediens, Beijing University of Chemical Technology, Beijing 100029, China.
Bioengineering (Basel, Switzerland)
|July 29, 2023
Summary
A novel sodium hyaluronate/carboxymethyl chitosan absorbable hemostatic foam (SHCF) offers rapid hemostasis and quick degradation. This multifunctional material shows significant potential for clinical use in controlling bleeding and preventing tissue adhesion.
Area of Science:
- Biomaterials Science
- Regenerative Medicine
- Surgical Innovation
Background:
- Current absorbable hemostatic materials have limitations including single coagulation mechanisms, slow degradation, and restricted clinical applications.
- There is a need for advanced hemostatic agents with enhanced functionality and improved biocompatibility for effective in vivo hemostasis.
Purpose of the Study:
- To develop and characterize a novel sodium hyaluronate/carboxymethyl chitosan absorbable hemostatic foam (SHCF) with enhanced hemostatic and degradation properties.
- To evaluate the efficacy of SHCF in preclinical bleeding models, including its hemostatic capacity, degradation profile, and anti-adhesion effects.
Main Methods:
- SHCF was synthesized by combining sodium hyaluronate and carboxymethyl chitosan through hydrogen bonding.
- The hemostatic performance was assessed using rabbit liver and porcine injury models (liver, uterine, bone).
- Degradation and metabolism studies were conducted to determine the in vivo clearance rate of SHCF.
Main Results:
- SHCF demonstrated rapid liquid absorption and transformed into a gel upon contact with blood, facilitating easier degradation.
- Significant reductions in hemostatic time (85%) and blood loss (80%) were observed in a rabbit liver bleeding model.
- Effective bleeding control and anti-tissue adhesion properties were confirmed in severe porcine injury models.
- SHCF exhibited rapid degradation, with 93% degradation within 24 hours and near-complete metabolism within three weeks.
Conclusions:
- The developed SHCF is a multifunctional absorbable hemostatic foam with rapid hemostasis, anti-adhesion capabilities, and swift degradation.
- SHCF presents considerable clinical potential as an advanced hemostatic agent for various in vivo applications.
- This innovative biomaterial addresses limitations of existing hemostatic materials, paving the way for improved surgical outcomes.
