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Thermosensation

Thermosensation

Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...

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Related Experiment Video

Updated: Jul 21, 2025

Non-Invasive Monitoring of Microvascular Oxygenation and Reactive Hyperemia using Hybrid, Near-Infrared Diffuse Optical Spectroscopy for Critical Care

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A Novel Intraoperative Mapping Device Detects the Thermodynamic Response Function.

Michael Iorga¹, Nils Schneider¹, Jaden Cho¹

¹Department of Radiology, Feinberg School of Medicine, Chicago, IL 60611, USA.

|July 29, 2023

Summary

This summary is machine-generated.

Infrared thermography can map brain activity by detecting temperature changes during surgery. This study identified a specific thermal impulse response function, improving brain mapping accuracy.

Keywords:

brain mapping functional neuroimaging image-guided neurosurgery infrared thermography intraoperative mapping

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Area of Science:

Neuroscience
Medical Imaging
Surgical Technology

Background:

Functional brain activation increases local temperature and perfusion.
Infrared thermography can visualize cortical surface temperature changes during surgery.
Quantitative spatiotemporal analysis of these thermal changes is lacking.

Purpose of the Study:

To develop and validate a novel intraoperative infrared thermography system.
To characterize the thermal impulse response function of the brain during functional activation.
To improve the accuracy of functional mapping in neurosurgery.

Main Methods:

Development of a novel intraoperative infrared thermography device and data collection software.
Validation in six patients undergoing awake craniotomy with motor and sensory mapping tasks.
Group principal component analysis to identify shared spatiotemporal patterns of cortical temperature changes.

Main Results:

Identification of a consistent thermal activation peak across patients.
Characterization of the thermal impulse response function with a 5-second onset delay and 10-second peak duration.
Generated functional maps showed strong correspondence with direct electrical stimulation results.

Conclusions:

The study demonstrates a previously unrecognized impulse response function for functional mapping using intraoperative infrared thermography.
This novel device and analysis provide a more quantitative approach to brain mapping.
The findings have significant implications for improving intraoperative neurosurgical guidance.