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Updated: Jul 21, 2025

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome
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Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome

Published on: July 5, 2024

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Circular RNA as a Novel Regulator and Promising Biomarker in Polycystic Ovary Syndrome

Tianrui Jing1,2, Yifan Wu1,2, Anran Wan1,2

  • 1Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200135, China.

Biomolecules
|July 29, 2023
PubMed

Insights

Circular RNAs (circRNAs) show potential as diagnostic biomarkers and therapeutic targets for Polycystic Ovary Syndrome (PCOS). Further research into their regulatory roles in PCOS progression is crucial for improved patient care.

Area of Science:

  • Endocrinology
  • Genetics
  • Reproductive Biology

Background:

  • Polycystic Ovary Syndrome (PCOS) is a common endocrine disorder affecting female fertility.
  • The precise pathogenesis of PCOS remains unclear, hindering effective diagnosis and treatment.
  • Novel biomarkers and therapeutic strategies are urgently needed for PCOS management.

Purpose of the Study:

  • To review the current understanding of circular RNAs (circRNAs) in the context of PCOS.
  • To elucidate the regulatory functions and molecular mechanisms of circRNAs in PCOS.
  • To explore the potential of circRNAs as diagnostic biomarkers and therapeutic targets for PCOS.

Main Methods:

  • Literature review of recent studies on circRNAs and PCOS.
  • Analysis of circRNA expression patterns and functions in PCOS pathogenesis.
  • Evaluation of circRNAs in follicular fluid as potential PCOS indicators.

Main Results:

  • CircRNAs are implicated in modulating key biological processes in PCOS, including cell proliferation, apoptosis, and steroidogenesis.
  • CircRNAs are detected in the follicular fluid of women with PCOS, suggesting diagnostic utility.
  • Specific circRNAs may serve as novel therapeutic targets for PCOS.

Conclusions:

  • CircRNAs play significant roles in the development and progression of PCOS.
  • circRNAs represent promising candidates for non-invasive diagnostic biomarkers for PCOS.
  • Targeting circRNAs offers a potential novel therapeutic avenue for PCOS treatment.
Keywords:
PCOSbiological functionsbiomarkerscircRNAstherapeutic targets

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