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Articles linked to this work by shared authors, journal, and citation graph.

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Neurotransmitter Genes in the Nucleus Accumbens That Are Involved in the Development of a Behavioral Pathology After Positive Fighting Experiences and Their Deprivation: A Conceptual Paradigm for Data Analysis.

International journal of molecular sciences·2025
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Expression Profiles of Genes Related to Serotonergic Synaptic Function in Hypothalamus of Hypertensive and Normotensive Rats in Basal and Stressful Conditions.

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Effect of Short-Term Restraint Stress on the Expression of Genes Associated with the Response to Oxidative Stress in the Hypothalamus of Hypertensive ISIAH and Normotensive WAG Rats.

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Effect of Short-Term Restraint Stress on the Hypothalamic Transcriptome Profiles of Rats with Inherited Stress-Induced Arterial Hypertension (ISIAH) and Normotensive Wistar Albino Glaxo (WAG) Rats.

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A Principal Components Analysis and Functional Annotation of Differentially Expressed Genes in Brain Regions of Gray Rats Selected for Tame or Aggressive Behavior.

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Animal Models of Hypertension (ISIAH Rats), Catatonia (GC Rats), and Audiogenic Epilepsy (PM Rats) Developed by

Marina A Ryazanova1, Vladislava S Plekanchuk1, Olga I Prokudina1

  • 1Federal Research Center, Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, Novosibirsk 630090, Russia.

Biomedicines
|July 29, 2023
PubMed
Summary

Breeding naturally manifesting animal models, like ISIAH rats for hypertension, offers a superior approach to studying complex human diseases. This method minimizes side effects compared to traditional interventions.

Keywords:
ISIAH rat strainanimal modelaudiogenic epilepsycatatoniagenetic catatonia rat strainhypertensionpendulum-like movements rat strainstereotypy

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Area of Science:

  • Genetics and Physiology
  • Animal Models of Human Disease
  • Pathogenesis Research

Background:

  • Widespread human diseases require research into genetic and physiological mechanisms.
  • Existing animal models (pharmacological, surgical, genetic) have significant limitations, including unintended side effects.
  • Need for models with natural pathology manifestation for accurate disease pathogenesis studies.

Purpose of the Study:

  • To review the value of genetically selected animal models for studying human diseases.
  • To describe three specific rat models developed through selective breeding.

Main Methods:

  • Selective breeding for target traits to create animal models.
  • Development of ISIAH rats (arterial hypertension), GC rats (catatonia), and PM rats (audiogenic epilepsy) via breeding.
  • Focus on models with naturally occurring pathologies.

Main Results:

  • Successfully developed three distinct rat models (ISIAH, GC, PM) through selective breeding.
  • These models exhibit natural manifestations of arterial hypertension, catatonia, and audiogenic epilepsy.
  • Selective breeding provides a valuable alternative to invasive methods for creating disease models.

Conclusions:

  • Genetically selected animal models, developed through breeding, are highly valuable for studying disease pathogenesis.
  • The ISIAH, GC, and PM rat models represent significant advancements in creating naturally manifesting disease models.
  • This approach overcomes limitations of traditional methods, offering more biologically relevant research tools.