Related Experiment Video

Updated: Jul 21, 2025

Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens
07:25

Isolation of Macrophage Subsets and Stromal Cells from Human and Mouse Myocardial Specimens

Published on: December 17, 2019

8.1K

Macrophages of the Cardiorenal Axis and Myocardial Infarction

Maria Kercheva1,2, Vyacheslav Ryabov1,2,3, Aleksandra Gombozhapova1,2

  • 1Cardiology Division, Siberian State Medical University, 2 Moscovsky Trakt, 634055 Tomsk, Russia.

Biomedicines
|July 29, 2023
PubMed

Insights

Kidney macrophage composition differs in fatal myocardial infarction (MI). Fatal MI patients showed more CD163+ macrophages, while controls had more CD163+, CD206+, and CD68+ cells. This suggests potential therapeutic targets.

Area of Science:

  • Renal pathology
  • Immunohistochemistry
  • Cardiovascular disease research

Background:

  • Macrophage (mf) infiltration in kidneys is implicated in various diseases.
  • Understanding kidney macrophage profiles in myocardial infarction (MI) is crucial for post-MI complication management.

Purpose of the Study:

  • To compare kidney macrophage composition between patients with fatal myocardial infarction (MI) and individuals without cardiovascular diseases (CVD).
  • To investigate the roles of M1 (CD80+) and M2 (CD163+, CD206+, stabilin-1+) macrophages in the kidneys post-MI.

Main Methods:

  • Autopsy-derived kidney tissue samples were analyzed.
  • Immunohistochemistry was employed using markers: CD68 (common mf), CD80 (M1 type), and CD163, CD206, stabilin-1 (M2 type).

Main Results:

  • Fatal MI patients exhibited a predominance of CD163+ macrophages.
  • Control subjects showed a higher prevalence of CD163+, CD206+, and CD68+ macrophages.
  • CD80+ and CD206+ cell counts decreased in the long-term MI group, indicating a biphasic response.

Conclusions:

  • Kidney macrophage composition is altered in fatal myocardial infarction.
  • Specific macrophage subsets (CD80+, CD206+) show dynamic changes post-MI.
  • Further research on CD80+ and CD206+ cells may reveal novel therapeutic targets for post-MI complications.
Keywords:
cardiac macrophagescardiac remodelinginflammationkidney macrophagesmyocardial infarction

More Related Videos

Phenotypic Characterization of Macrophages from Rat Kidney by Flow Cytometry07:14

Phenotypic Characterization of Macrophages from Rat Kidney by Flow Cytometry

Published on: October 18, 2016

14.9K
Isolation and Culture of Resident Cardiac Macrophages from the Murine Sinoatrial and Atrioventricular Node08:43

Isolation and Culture of Resident Cardiac Macrophages from the Murine Sinoatrial and Atrioventricular Node

Published on: May 7, 2021

4.4K

Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
9
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
463
Pathophysiology of Heart Failure01:17

Pathophysiology of Heart Failure

Heart failure (HF) is a progressive syndrome involving ventricles that leads to inadequate cardiac output. It can be classified based on location and output or ejection fraction. Ejection fraction (EF) is an essential measurement in the diagnosis and surveillance of HF. Reduced EF corresponds to systolic heart failure (HFrEF). However, HF with preserved ejection fraction (HFpEF) is becoming increasingly prevalent. Also known as diastolic HF, this form of HF is related to aging. The...
1.6K
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
16
Inflammation01:38

Inflammation

Overview
53.9K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
15