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Published on: May 24, 2021
Free-Breathing and Single-Breath Hold Compressed Sensing Real-Time MRI of Right Ventricular Function in Children with
Christoph Treutlein1, Martin Georg Zeilinger1, Sven Dittrich2
1Institute of Radiology, University Hospital of Erlangen, Friedrich Alexander University Erlangen-Nürnberg, 91054 Erlangen, Germany.
Insights
Real-time cardiac MRI using compressed sensing free-breathing (CS-FB) and breath-hold (CS-BH) provides accurate right ventricular (RV) function assessment in children with congenital heart disease (CHD). These methods significantly reduce scan times compared to standard techniques.
Area of Science:
- Cardiovascular Imaging
- Pediatric Cardiology
- Medical Physics
Background:
- Congenital heart disease (CHD) requires regular monitoring of right ventricular (RV) function.
- Standard cine cardiac magnetic resonance (cMRI) for RV assessment involves lengthy breath-holds.
- Faster imaging techniques are needed for pediatric cardiac MRI.
Purpose of the Study:
- To compare RV functional parameters in pediatric CHD patients using real-time compressed sensing (CS) cine cMRI (single/double breath-hold [BH] and free-breathing [FB]) against standard retrospective segmented multi-breath hold (RMB) cine cMRI.
- To evaluate image quality and scan times of different cMRI techniques.
Main Methods:
- Twenty pediatric patients with surgically repaired CHD underwent 3T cMRI.
- Acquisition included single/double BH, FB, and RMB cine cMRI sequences for continuous axial RV imaging.
- Image quality was qualitatively assessed, and RV volumes were quantitatively analyzed.
Main Results:
- Retrospective segmented multi-breath hold (RMB) provided the best image quality (4.5/5), though CS-FB and CS-BH (3.9 and 3.6, respectively) were diagnostic.
- RV functional parameters were comparable across all methods (difference < 5%).
- Scan times were significantly reduced with CS-FB (24 ± 7 s) and CS-BH (44 ± 38 s) compared to RMB (261 ± 68 s).
Conclusions:
- Compressed sensing free-breathing (CS-FB) and breath-hold (CS-BH) real-time cine cMRI yield diagnostic image quality in pediatric CHD.
- These techniques accurately measure RV function with significantly reduced scan times compared to RMB.
- Real-time CS cMRI offers a promising alternative for efficient RV functional assessment in children with CHD.
Abstract:
(1) Purpose: to compare right ventricular (RV) functional parameters in children with surgically repaired congenital heart disease (CHD) using single/double breath hold (BH) and free-breathing (FB) real-time compressed sensing (CS) cine cardiac magnetic resonance (cMRI) with standard retrospective segmented multi breath hold (RMB) cine cMRI. (2) Methods: Twenty patients with CHD underwent BH and FB, as well as RMB cine cMRI, at 3T to obtain a stack of continuous axial images of the RV. Two radiologists independently performed qualitative analysis of the image quality (rated on a 5-point scale; 1 = non-diagnostic to 5 = excellent) and quantitative analysis of the RV volume measurements. (3) Results: The best image quality was provided by RMB (4.5; range 2-5) compared to BH (3.9; range 3-5; p = 0.04) and FB (3.6; range 3-5; p < 0.01). The RV functional parameters were comparable among BH, FB, and RMB with a difference of less than 5%. The scan times for BH (44 ± 38 s, p < 0.01) and FB (24 ± 7 s, p < 0.01) were significantly reduced compared to for RMB (261 ± 68 s). (4) Conclusions: CS-FB and CS-BH real-time cine cMRI in children with CHD provides diagnostic image quality with excellent accuracy for measuring RV function with a significantly reduced scan time compared to RMB.
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