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Non-Coding RNAs in Human Health and Diseases
1Department of Human Nutrition, Foods, and Exercise, Virginia Tech, Blacksburg, VA 24060, USA.
Genes
|July 29, 2023
Summary
Non-coding RNAs (ncRNAs) are abundant but poorly understood. This collection explores their roles in various systems and diseases, highlighting potential therapeutic targets.
Area of Science:
- Molecular Biology
- Genomics
- Biochemistry
Background:
- Non-coding RNAs (ncRNAs) represent a significant portion of the transcriptome, yet their functions, regulation, and interactions remain largely uncharacterized compared to messenger RNAs (mRNAs).
- Genetic and epigenetic variations, including single nucleotide variants (SNVs), deletions, insertions, and modifications to DNA/histones, are increasingly recognized to influence ncRNA regulation and function.
- The complexity of the ncRNA landscape presents a major challenge in understanding gene expression and cellular processes.
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