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Treatment Harms in Paediatric Primary Care

David M Reith1, Sharon Leitch2, Kyle Eggleton3

  • 1Dean's Department, Otago Medical School, University of Otago, Dunedin 9016, New Zealand.

International Journal of Environmental Research and Public Health
|July 29, 2023
PubMed

Insights

This study found that medication-related harm (MRH) is the most common health system harm in children and adolescents. Increased consultations correlate with a higher risk of harm in this population.

Area of Science:

  • Pediatric health outcomes
  • Public health surveillance
  • Medication safety in youth

Background:

  • Health system harms in children are under-documented.
  • Understanding pediatric harm epidemiology is crucial for targeted interventions.
  • General practice records offer a valuable data source for studying these harms.

Purpose of the Study:

  • To determine the epidemiology of health system harms in children and adolescents (≤20 years).
  • To identify risk factors associated with these harms.
  • To specifically investigate medication-related harm (MRH) in pediatric populations.

Main Methods:

  • The SHARP study analyzed 9076 patient records from 44 New Zealand general practices.
  • A 3-year study period captured data on "harm" defined as disease, injury, disability, suffering, or death from the health system.
  • Epidemiological rates and risk factors were calculated for various harm types, including MRH.

Main Results:

  • 193 harms were identified in 141 children and adolescents.
  • The overall annualised rate of harm was 36/1000 population.
  • Medication-related harm (MRH) was the most frequent type (20/1000), with anti-infectives being the most implicated drug group.

Conclusions:

  • Treatment-related harm in children is less frequent than in adults.
  • Medication-related harm is the primary type of health system harm in pediatric patients.
  • The risk of harm escalates with an increased number of patient consultations.

Keywords:
adolescentdrug utilisationgeneral practiceharmpaediatric

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