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Related Concept Videos

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Cardiac biomarkers are enzymes, proteins, and hormones released into the blood when cardiac cells are injured. They are powerful tools for triaging.
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Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
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Pneumonia poses the potential for numerous complications that warrant consideration. These complications include the following:
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Apelin-13 as a Potential Biomarker in Critical Illness.

Marin Gergics1,2, Gréta Pham-Dobor1,2, Csilla Kurdi2,3

  • 11st Department of Internal Medicine, Medical School, University of Pécs, 7624 Pécs, Hungary.

Journal of Clinical Medicine
|July 29, 2023
PubMed
Summary

Serum apelin-13 shows potential as a prognostic biomarker in critical illness. It, along with free cortisol, independently predicts survival, particularly in non-septic patients.

Keywords:
CRHapelin-13copeptincritical illnessfree cortisol

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Area of Science:

  • Endocrinology
  • Critical Care Medicine
  • Biomarker Discovery

Background:

  • The adrenocortical system and copeptin are established prognostic markers in critical illness.
  • The predictive value of apelin-13 in critically ill patients remains largely uncharacterized.

Purpose of the Study:

  • To investigate the prognostic role of apelin-13.
  • To compare apelin-13 with free cortisol, aldosterone, CRH, and copeptin as survival predictors.

Main Methods:

  • Prospective observational study of 124 critically ill patients.
  • Correlation of serum apelin-13 and other hormone levels with clinical parameters and survival outcomes.

Main Results:

  • Serum apelin-13 concentrations were higher in survivors (2477 pg/mL) versus non-survivors (1161 pg/mL), p=0.054.
  • Apelin-13 and CRH showed a strong positive correlation (r=0.685, p<0.001) and were higher in surviving non-septic patients.
  • Apelin-13 and free cortisol were independent predictors of survival in multivariate analysis.

Conclusions:

  • Serum apelin-13 may enhance prognostic predictions in early critical illness.
  • Apelin-13 offers additional prognostic value beyond free cortisol, especially in non-septic patients.