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The Role and Mechanism of MicroRNA 21 in Osteogenesis: An Update
Revatyambigai Subramaniam1, Ubashini Vijakumaran1, Lohashenpahan Shanmuganantha1
1Centre for Tissue Engineering and Regenerative Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia, Cheras 56000, Malaysia.
International Journal of Molecular Sciences
|July 29, 2023
Summary
MicroRNA 21 (miR21) plays a dual role in bone metabolism. Exogenous miR21 shows promise for accelerating new bone synthesis and treating bone loss conditions like osteoporosis.
Area of Science:
- Biochemistry
- Molecular Biology
- Regenerative Medicine
Background:
- MicroRNAs regulate gene expression post-translationally.
- MicroRNA 21 (miR21) is abundant and crucial for bone homeostasis.
- Exogenous microRNAs are potential therapeutic agents.
Purpose of the Study:
- To review the role and mechanism of human miR21 (hsa-miR21) in bone regulation.
- To explore exogenous miR21 as a strategy for promoting osteogenesis.
- To assess the therapeutic potential of miR21 in bone regenerative medicine.
Main Methods:
- Literature review of studies on miR21 in bone metabolism.
- Analysis of in vitro and in vivo experimental data.
- Evaluation of pathways mediated by miR21.
Main Results:
- miR21 exhibits a dual role in bone metabolism, affecting both formation and resorption.
- Exogenous miR21 accelerates new bone synthesis in models of bone loss.
- Evidence supports miR21's role in regulating bone homeostasis.
Conclusions:
- miR21 is a key regulator of bone metabolism.
- Exogenous miR21 is a viable strategy for promoting osteogenesis.
- Further research into exogenous miR21 for bone regenerative therapy is warranted.
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