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Published on: September 28, 2015
Bradykinin Metabolism and Drug-Induced Angioedema
Sylwia Smolinska1, Darío Antolín-Amérigo2, Florin-Dan Popescu3
1Department of Clinical Immunology, Wroclaw Medical University, 50-368 Wroclaw, Poland.
Abstract:
Bradykinin (BK) metabolism and its receptors play a central role in drug-induced angioedema (AE) without urticaria through increased vascular permeability. Many cardiovascular and diabetic drugs may cause BK-mediated AE. Angiotensin-converting enzyme inhibitors (ACEIs) and neprilysin inhibitors impair BK catabolism. Dipeptidyl peptidase-IV (DPP-IV) inhibitors reduce the breakdown of BK and substance P (SP). Moreover, angiotensin receptor blockers, thrombolytic agents, and statins may also induce BK-mediated AE. Understanding pathophysiological mechanisms is crucial for preventing and treating drug-induced AE.
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