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Optimization of a Multiplex RNA-based Expression Assay Using Breast Cancer Archival Material
Published on: August 1, 2018
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Calcium-Sensing Receptor Expression in Breast Cancer
Iva Busic-Pavlek1, Ivo Dumic-Cule2,3, Lucija Kovacevic2
1Clinical Department of Diagnostic and Interventional Radiology, University Hospital Centre Split, Spinciceva 1, 21000 Split, Croatia.
International Journal of Molecular Sciences
|July 29, 2023
Summary
High calcium-sensing receptor (CaSR) expression in breast cancer correlates with larger tumor size, HER2 positivity, and metastasis. This suggests CaSR may indicate a poorer prognosis for invasive breast carcinoma patients.
Area of Science:
- Oncology
- Molecular Biology
- Biochemistry
Background:
- The calcium-sensing receptor (CaSR) is vital for calcium homeostasis.
- Aberrant CaSR signaling is implicated in various cancers, including breast tumors.
Purpose of the Study:
- To investigate the expression of CaSR in invasive breast carcinoma of no special type (NST).
- To explore the correlation between CaSR expression and clinicopathological features of breast cancer.
Main Methods:
- Retrospective analysis of 79 patients with invasive breast carcinoma NST.
- Immunohistochemistry on core needle biopsy samples to assess CaSR expression.
- Correlation analysis with patient age, tumor size, hormone receptor status, HER2 status, Ki-67, tumor grade, and TNM staging.
Main Results:
- CaSR expression positively correlated with tumor size (p=0.001) and HER2 receptor status (p=0.002).
- Negative correlation observed between CaSR and Estrogen Receptor (ER) expression (p=0.033).
- Increased CaSR associated with lymph node involvement, distant metastasis (p=0.001, p=0.038), and higher Ki-67 index (p=0.042).
Conclusions:
- Higher CaSR expression in breast cancer is linked to aggressive features.
- CaSR may serve as a prognostic marker for poor outcomes in breast cancer, irrespective of subtype.
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