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Interactions between circRNAs and miR-141 in Cancer: From Pathogenesis to Diagnosis and Therapy

Małgorzata Guz1, Witold Jeleniewicz1, Marek Cybulski1

  • 1Department of Biochemistry and Molecular Biology, Medical University of Lublin, 20-093 Lublin, Poland.

International Journal of Molecular Sciences
|July 29, 2023
PubMed

Insights

Circular RNAs (circRNAs) and microRNAs (miRNAs) are key in cancer development. This study reviews circRNA/miR-141 interactions, highlighting their role in cancer and potential as therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Non-coding RNAs (ncRNAs), including circular RNAs (circRNAs) and microRNAs (miRNAs), are integral to cancer pathogenesis.
  • Aberrant ncRNA expression drives carcinogenesis, with circRNAs acting as crucial regulators within the competing endogenous RNA (ceRNA) network.
  • CircRNAs function as miRNA sponges, modulating miRNA accessibility to mRNA targets and influencing cellular homeostasis.

Purpose of the Study:

  • To review the current understanding of circRNA and miR-141 interactions in malignant transformation.
  • To emphasize the biological roles of circRNA/miR-141/mRNA networks in cancer.
  • To explore the potential of these networks as novel anti-cancer therapeutic targets.

Main Methods:

  • Literature review and synthesis of existing research on circRNA-miRNA interactions.
  • Analysis of the molecular mechanisms involving circRNAs, miR-141, and their mRNA targets.
  • Focus on the ceRNA network's role in cancer biology.

Main Results:

  • CircRNAs act as miRNA sponges, with imbalances in circRNA/miRNA interactions contributing to various pathologies, notably cancer.
  • Specific circRNA interactions with miR-141 (a miR-200 family member) are implicated in malignant transformation.
  • The circRNA/miR-141/mRNA regulatory network plays a significant role in cancer development.

Conclusions:

  • The circRNA/miR-141 axis is a critical component of cancer biology.
  • Understanding these molecular interactions provides insights into carcinogenesis.
  • Targeting circRNA/miR-141/mRNA networks offers promising avenues for future anti-cancer therapies.
Keywords:
cancercircRNAcircRNA-miRNA-mRNA regulatory networkdiagnosismiR-141microRNAncRNAtherapy

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