Related Experiment Video
Updated: Jul 21, 2025
09:35
A Protocol for Using Gene Set Enrichment Analysis to Identify the Appropriate Animal Model for Translational Research
Published on: August 16, 2017
17.9K
Aligning Cross-Species Interactomes for Studying Complex and Chronic Diseases.
Marianna Milano1,2, Pietro Cinaglia2,3, Pietro Hiram Guzzi2,4
1Department of Experimental and Clinical Medicine, University Magna Græcia, 88100 Catanzaro, Italy.
Life (Basel, Switzerland)
|July 29, 2023
Summary
This study compares protein-protein interaction networks in humans and C. elegans to understand neurodegenerative diseases like Alzheimer's and Parkinson's. Computational analysis reveals functionally related subregions, aiding the study of complex disease progression.
Area of Science:
- Computational Biology
- Neuroscience
- Genetics
Background:
- Neurodegenerative diseases (NDs) involve progressive neuron loss, including Alzheimer's disease (AD) and Parkinson's disease (PD).
- Protein-protein interaction (PPI) networks are valuable tools for understanding disease mechanisms.
- Caenorhabditis elegans serves as a model organism due to conserved gene orthologs with humans.
Purpose of the Study:
- To compare human and C. elegans PPI networks relevant to AD and PD using computational techniques.
- To identify functionally related subregions within these networks.
Main Methods:
- Utilized the L-HetNetAligner algorithm for local network alignment (LNA) between human and C. elegans PPI networks.
- Applied computational techniques for inter-species PPI network analysis.
Main Results:
- The L-HetNetAligner successfully identified local alignments representing functionally related subregions in the PPI networks.
- Demonstrated the capability of LNA to uncover conserved functional modules across species.
Conclusions:
- Local network alignment is an effective method for extracting functionally related modules from PPI networks.
- This approach can be applied to study the complex progression of neurodegenerative diseases.
Related Concept Videos
02:26Protein Networks
4.0K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.0K
02:02Genomics
36.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
36.5K