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Updated: Jul 21, 2025
07:59
A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
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Panapophenanthrin, a Rare Oligocyclic Diterpene from Panus strigellus
Natalia A Llanos-López1,2, Sherif Saeed Ebada1,3, Aída M Vasco-Palacios4
1Department of Microbial Drugs, Helmholtz Centre for Infection Research (HZI) and German Centre for Infection Research (DZIF), DZIF Partner Site Hannover-Braunschweig, Inhoffenstrasse 7, 38124 Braunschweig, Germany.
Metabolites
|July 29, 2023
Summary
A new fungal metabolite, panapophenanthrin, was isolated and found to have potent cytotoxic activity against cancer cell lines. Other compounds showed moderate antimicrobial effects.
Area of Science:
- Natural Product Chemistry
- Mycology
- Medicinal Chemistry
Background:
- Fungal secondary metabolites are a rich source of biologically active compounds.
- The exploration of fungal biodiversity continues to yield novel chemical structures.
Purpose of the Study:
- To isolate and characterize new metabolites from the fungus *Panus strigellus*.
- To evaluate the antimicrobial and cytotoxic potential of isolated compounds.
Main Methods:
- Isolation of secondary metabolites using chromatographic techniques.
- Structure elucidation via Nuclear Magnetic Resonance (NMR) spectroscopy and High-Resolution Electrospray Ionization Mass Spectrometry (HR-ESI-MS).
- Determination of absolute configuration using Time-Dependent Density Functional Theory - Electronic Circular Dichroism (TDDFT-ECD) calculations.
Main Results:
- A new oligocyclic diterpenoidal derivative, panapophenanthrin (1), was isolated along with known compounds panepophenanthrin (2) and dihydrohypnophilin (3).
- Panapophenanthrin (1) demonstrated potent cytotoxic activity against mouse fibroblast (L929) and human endocervical adenocarcinoma (KB3.1) cell lines.
- Compounds 1 and 3 exhibited moderate to weak antimicrobial activities.
Conclusions:
- Panapophenanthrin represents a novel diterpenoid with significant cytotoxic potential.
- This study highlights *Panus strigellus* as a source of bioactive fungal metabolites.
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