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Author Spotlight: Advancing Therapeutics to Treat Vibriosis in Humans and Aquatic Organisms
Published on: May 31, 2024
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Desulfovibrio in the Gut: The Enemy within?
Sudha B Singh1, Amanda Carroll-Portillo2, Henry C Lin2,3
1Biomedical Research Institute of New Mexico, Albuquerque, NM 87108, USA.
Microorganisms
|July 29, 2023
Summary
Sulfate-reducing bacteria Desulfovibrio (DSV) can overgrow in the gut and are linked to various diseases. This review explores their role in disease pathology and potential causal mechanisms.
Area of Science:
- Microbiology
- Human Health
- Gut Microbiome Research
Background:
- Desulfovibrio (DSV) are common sulfate-reducing bacteria (SRB) found in the environment and human gut.
- While typically commensal, DSV can act as opportunistic pathobionts, overgrowing during disease states.
- An increasing body of evidence links DSV blooms to various intestinal and extra-intestinal diseases.
Purpose of the Study:
- To review the current understanding of the association between DSV and human diseases.
- To explore the potential mechanisms by which DSV may contribute to disease development.
- To highlight DSV as a predominant SRB genus in the gut.
Main Methods:
- Literature review of studies investigating Desulfovibrio and disease.
- Analysis of correlations between DSV overgrowth and human pathologies.
- Examination of proposed pathogenetic mechanisms.
Main Results:
- DSV are frequently found in increased abundance during various diseases.
- Evidence suggests a potential causal role for DSV in disease progression.
- DSV are the most abundant SRB genus in the human gut.
Conclusions:
- DSV overgrowth is correlated with numerous human diseases.
- Further research is needed to elucidate the precise mechanisms of DSV pathogenicity.
- Understanding DSV's role is crucial for developing targeted therapeutic strategies.
Keywords:
DesulfovibrioParkinson’s diseasehydrogen sulfide (H2S)inflammatory bowel diseaselipopolysaccharide (LPS)sulfate reducing bacteria (SRB)More Related Videos
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