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Anti-Inflammatory Effects of Dietary Polyphenols through Inhibitory Activity against Metalloproteinases

Takuji Suzuki1, Tomokazu Ohishi2,3, Hiroki Tanabe4

  • 1Department of Food Science and Nutrition, Faculty of Human Life and Science, Doshisha Women's College of Liberal Arts, Kamigyo-ku, Kyoto 602-0893, Japan.

Molecules (Basel, Switzerland)
|July 29, 2023
PubMed

Insights

Dietary polyphenols can combat inflammatory diseases by suppressing matrix metalloproteinases (MMPs). These compounds reduce MMP gene expression and enzyme activity, offering a potential therapeutic strategy for conditions like arthritis and Alzheimer's disease.

Area of Science:

  • Biochemistry
  • Pharmacology
  • Molecular Biology

Background:

  • Matrix metalloproteinases (MMPs) are crucial enzymes implicated in various diseases, including cancer, cardiovascular conditions, diabetes, obesity, and neurological disorders.
  • Inflammation is a key characteristic of many diseases where MMPs are often upregulated, such as osteoarthritis, rheumatoid arthritis, inflammatory bowel disease, and Alzheimer's disease.

Purpose of the Study:

  • To investigate the potential anti-inflammatory effects of dietary polyphenols on matrix metalloproteinases (MMPs).
  • To elucidate the mechanisms by which polyphenols may suppress MMP gene expression and enzyme activity in inflammatory diseases.

Main Methods:

  • Review of clinical studies, patient-derived human samples, animal studies, and cellular experiments.
  • Analysis of polyphenol mechanisms, including the downregulation of reactive oxygen species (ROS) and direct inhibition of MMP activity.
  • Utilizing molecular docking analyses to understand polyphenol-MMP interactions.

Main Results:

  • Polyphenols demonstrate beneficial effects against inflammatory diseases by suppressing MMPs.
  • Key mechanisms involve reducing ROS that drive MMP expression and directly inhibiting MMP enzyme activity.
  • Molecular docking provides structural insights into polyphenol-MMP interactions.

Conclusions:

  • Dietary polyphenols show promise as therapeutic agents for inflammatory diseases by targeting MMPs.
  • Understanding polyphenol-MMP interactions can guide the development of novel polyphenol-based anti-inflammatory drugs.
Keywords:
EGCGchlorogenic acidcurcumindietary polyphenolsgenisteininflammatory diseasesmatrix metalloproteinasesmolecular docking analysisquercetinresveratrol

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