Related Experiment Video
Updated: Jul 20, 2025
09:15
Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
Published on: February 24, 2023
3.5K
Application of Cyclodextrin for Cancer Immunotherapy
Xiaojie Wei1, Cui-Yun Yu1, Hua Wei1
1Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, University of South China, Hengyang 421001, China.
Molecules (Basel, Switzerland)
|July 29, 2023
Summary
Cyclodextrins (CDs) enhance tumor immunotherapy by improving drug solubility and overcoming cancer cell immune escape. This review details CD applications for superior anticancer efficacy in novel immunotherapeutic delivery systems.
Area of Science:
- Oncology
- Immunology
- Materials Science
Background:
- Tumor immunotherapy offers long-term benefits against cancer metastasis and recurrence.
- Poor water solubility of immune modulators and tumor cell immune escape limit immunotherapy efficacy.
- Cyclodextrins (CDs) possess unique hydrophobic/hydrophilic properties beneficial for drug delivery.
Purpose of the Study:
- To comprehensively review the application of cyclodextrins (CDs) in tumor immunotherapy.
- To emphasize the role, function, and strategies of CDs in mediating cancer immunotherapy.
- To summarize research progress and facilitate the development of CD-based immunotherapeutics.
Main Methods:
- Literature review of studies utilizing cyclodextrins for cancer immunotherapy.
- Analysis of CD properties and their impact on immune modulator delivery.
- Synthesis of reported strategies for CD-mediated immunotherapy.
Main Results:
- CDs improve the solubility of poorly soluble immune modulators.
- CDs help overcome tumor cell immune escape mechanisms.
- Various CD-based delivery systems show enhanced anticancer efficacy.
Conclusions:
- Cyclodextrins are promising building units for advanced cancer immunotherapy.
- CDs offer effective strategies to address current limitations in tumor immunotherapy.
- Further development of CD-based systems can lead to superior anticancer treatments.
Related Concept Videos
01:27Tumor Immunotherapy
558
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
558
02:34Inhibition of Cdk Activity
4.8K
The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
4.8K
01:30Cancer Vaccines
405
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
405
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K