Cyclic Peptides in Pipeline: What Future for These Great Molecules?

Area of Science:

• Pharmaceutical Science
• Medicinal Chemistry

Background:

• Cyclic peptides are established therapeutics with approved applications as antibiotics, antifungals, anticancer agents, and immunosuppressants.
• The cyclic structure offers improved pharmacokinetic and pharmacodynamic properties compared to linear peptides.
• Advances in synthesis, computational, and in vitro methods are fueling renewed interest in cyclic peptides.

Purpose of the Study:

• To review the therapeutic potential of cyclic peptides.
• To discuss general aspects of cyclic peptide synthesis and development.
• To provide an overview of approved cyclic peptides and those in clinical trials.

Main Methods:

• Literature review of approved and investigational cyclic peptides.
• Summary of advancements in cyclic peptide synthesis and development methodologies.
• Analysis of pharmacokinetic and pharmacodynamic advantages of cyclic structures.

Main Results:

• 53 cyclic peptides have received regulatory approval for therapeutic use.
• Numerous cyclic peptides are currently undergoing clinical trials for diverse medical conditions.
• The review highlights the expanding role and versatility of cyclic peptides in medicine.

Conclusions:

• Cyclic peptides represent a significant and growing class of therapeutic agents.
• Ongoing research and development continue to expand the clinical applications of cyclic peptides.
• The unique properties of cyclic peptides ensure their continued importance in drug discovery and development.