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Therapies Targeting Immune Cells in Tumor Microenvironment for Non-Small Cell Lung Cancer

Wei Ye1, Meiye Li1, Kewang Luo1,2

  • 1School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510091, China.

Pharmaceutics
|July 29, 2023
PubMed

The tumor microenvironment (TME) plays critical roles in immune modulation and tumor malignancies in the process of cancer development. Immune cells constitute a significant component of the TME and influence the migration and metastasis of tumor cells. Recently, a number of therapeutic approaches targeting immune cells have proven promising and have already been used to treat different types of cancer. In particular, PD-1 and PD-L1 inhibitors have been used in the first-line setting in non-small cell lung cancer (NSCLC) with PD-L1 expression ≥1%, as approved by the FDA. In this review, we provide an introduction to the immune cells in the TME and their efficacies, and then we discuss current immunotherapies in NSCLC and scientific research progress in this field.

Keywords:
NSCLCTMEimmune cellsimmunotherapies

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