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Microorganisms in Medicine and Therapeutics

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Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.

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Updated: Jul 20, 2025

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Author Spotlight: Identifying Compensatory Pathways in Malaria Parasites Containing Hypomorphic Allele of Essential Protein Kinases

Published on: November 22, 2024

Novel Therapeutics for Malaria.

Haitham Alaithan^1,2, Nirbhay Kumar³, Mohammad Z Islam⁴

¹Veterans Affairs Medical Center, Washington, DC 20422, USA.

|July 29, 2023

Summary

This summary is machine-generated.

Malaria remains a critical global health threat, with drug-resistant parasites challenging current treatments. New antimalarial therapies targeting novel pathways are urgently needed to combat this deadly disease.

Keywords:

Plasmodium antimalarial drug malaria novel

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Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Methods to Investigate the Regulatory Role of Small RNAs and Ribosomal Occupancy of Plasmodium falciparum

Published on: December 4, 2015

Area of Science:

* Infectious Diseases
* Parasitology
* Drug Discovery

Background:

* Malaria, caused by Plasmodium parasites, is a major cause of death and illness globally, particularly in tropical and subtropical regions.
* An estimated 247 million cases and 619,000 deaths occurred in 2021, highlighting the disease's significant public health impact.
* Emerging resistance to antimalarial drugs poses a substantial challenge to global control efforts.

Purpose of the Study:

* To review current antimalarial therapies and their limitations.
* To explore novel drug targets and emerging therapeutic strategies against malaria.
* To address the urgent need for new antimalarial drugs effective against resistant strains.

Main Methods:

* Comprehensive literature review of current and emerging antimalarial research.
* Analysis of Plasmodium physiology to identify potential drug intervention targets.
* Evaluation of drug development pipelines for novel antimalarial candidates.

Main Results:

* Over 10 novel antimalarial drug candidates targeting unique pathways are in clinical development.
* Understanding Plasmodium physiology has revealed new targets for therapeutic intervention.
* Existing therapies face significant challenges due to widespread drug resistance.

Conclusions:

* Development of new antimalarial drugs with novel mechanisms of action is critical.
* Targeting identified pathways in Plasmodium offers promising avenues for combating resistant malaria.
* Continued research and development are essential to overcome the global malaria burden.