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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Controlled Delivery of Celecoxib-β-Cyclodextrin Complexes from the Nanostructured Titanium Dioxide Layers.

Magdalena Jarosz1, Jakub Latosiński1, Paweł Gumułka2,3

  • 1Department of Physical Chemistry & Electrochemistry, Faculty of Chemistry, Jagiellonian University, Gronostajowa 2, 30-387 Krakow, Poland.

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This study developed a nanostructured titanium dioxide (TiO2) drug delivery system for the anti-inflammatory drug celecoxib, utilizing its complex with beta-cyclodextrin for enhanced pain treatment.

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celecoxibdrug deliveryinclusion complexesnanostructured titanium dioxideβ-cyclodextrin

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Pharmaceutical Sciences

Background:

  • Nanostructured titanium dioxide (TiO2) shows promise for drug delivery applications.
  • Celecoxib, an anti-inflammatory drug, can be formulated into inclusion complexes with beta-cyclodextrin.
  • Developing effective drug delivery systems is crucial for targeted and sustained drug release.

Purpose of the Study:

  • To create a functional drug delivery system using anodic TiO2 for celecoxib and its beta-cyclodextrin complex.
  • To optimize the composition of celecoxib-beta-cyclodextrin complexes.
  • To evaluate the drug release profile from TiO2 nanostructures.

Main Methods:

  • Synthesis and characterization of celecoxib-beta-cyclodextrin complexes using ITC, DSC, FT-IR, 1H NMR, and SEM.
  • Electrochemical oxidation to synthesize nanostructured TiO2 layers (60 nm pore diameter, 1.60 µm thickness).
  • Loading TiO2 layers with pure celecoxib and the celecoxib-beta-cyclodextrin complex, followed by release studies.

Main Results:

  • Optimal composition of celecoxib-beta-cyclodextrin complexes was determined.
  • Nanostructured TiO2 layers were successfully synthesized and characterized.
  • Effective drug release of celecoxib from TiO2 layers was observed over 24 hours, with an initial burst release followed by continuous release.

Conclusions:

  • Nanostructured TiO2 serves as an effective drug delivery system for celecoxib, particularly when complexed with beta-cyclodextrin.
  • This system offers a viable approach for sustained drug availability, potentially aiding in pain management, such as in orthopedic surgery.
  • The combination of TiO2 nanostructures and beta-cyclodextrin-celecoxib complexes presents a promising advanced drug delivery platform.