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Genetic variation and plasma creatine kinase activity.
Acta Geneticae Medicae Et Gemellologiae
|January 1, 1986
Summary
Plasma creatine kinase (CK) levels show skewed distributions. Twin study reveals genetic and environmental factors influence CK, with greater environmental impact in men and a potential genetic basis for very high CK values in some males.
Area of Science:
- Biochemistry
- Human Genetics
- Twin Studies
Background:
- Plasma creatine kinase (CK) distribution is typically skewed, complicating variation analysis.
- Understanding CK level determinants is crucial for biochemical and genetic research.
Purpose of the Study:
- To investigate the sources of variation in plasma creatine kinase (CK) levels.
- To analyze the influence of genetic and environmental factors on plasma CK in twins.
Main Methods:
- Studied plasma CK levels in 206 pairs of twins.
- Analyzed data by separating distributions into two apparent Gaussian frequencies.
- Differentiated results based on CK levels (less than 300 iu/1) and sex.
Main Results:
- Identified two distinct Gaussian frequency distributions for plasma CK.
- Main distribution (CK < 300 iu/1) influenced by shared genetic factors in both sexes.
- Environmental factors significantly impact CK levels, with a greater effect observed in men.
- A genetic basis is suggested for very high CK values observed in some men.
Conclusions:
- Plasma CK variation is influenced by both genetic and environmental factors.
- Environmental influences on plasma CK are more pronounced in men.
- Specific genetic factors may contribute to exceptionally high CK levels in certain male individuals.