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Related Experiment Video

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Subretinal Transplantation of Human Embryonic Stem Cell Derived-retinal Pigment Epithelial Cells into a Large-eyed Model of Geographic Atrophy
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Integrated High-Temporal-Resolution and High-Density Subretinal Prosthesis Using a Correlated Double-Sampling

Hosung Kang1, Jungyeon Kim2,3, Jungsuk Kim4

  • 1Department of Medical Science, Korea University, Seoul 02841, Republic of Korea.

Sensors (Basel, Switzerland)
|July 29, 2023
PubMed
Summary

This study introduces a 1600-pixel neural stimulator for subretinal prostheses, utilizing a correlated double-sampling readout (DSR) circuit to enhance vision restoration. The device achieves high temporal resolution and improved signal-to-noise ratio for better visual perception.

Keywords:
correlated double samplingcurrent amplifierhigh-density pixelsimage sensorimplantable deviceneural stimulatorsubretinal prosthesistemporal resolution

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Electrical Engineering

Background:

  • Subretinal prostheses aim to restore vision by electrically stimulating retinal neurons.
  • Existing devices face challenges in achieving high spatial and temporal resolution for naturalistic vision.
  • Active pixel sensors (APS) are crucial for image acquisition in retinal implants.

Purpose of the Study:

  • To develop and evaluate a 1600-pixel integrated neural stimulator for subretinal prostheses.
  • To improve the signal-to-noise ratio (SNR) and temporal resolution of restored vision.
  • To reduce pixel size and power consumption for a more effective retinal implant.

Main Methods:

  • Integration of a correlated double-sampling readout (DSR) circuit with an active pixel sensor (APS) array.
  • Utilization of a 5x5-pixel tile design to enhance SNR and reduce pixel area.
  • Implementation of a low-mismatch reference generator for consistent pulse shaping.
  • Fabrication using a 0.18 μm 1P6M CMOS process.

Main Results:

  • Achieved a high signal-to-noise ratio (SNR) with a short integration time.
  • Demonstrated improved temporal and spatial resolutions for restored vision.
  • The 1600-pixel chip (4.3 mm x 3.3 mm) consumed an average power of 3.4 mW.
  • Stimulus current patterns were successfully determined for LCD projector illuminations.

Conclusions:

  • The proposed high-density stimulation array chip significantly enhances temporal resolution.
  • The DSR circuit and optimized pixel design contribute to improved visual perception.
  • This integrated neural stimulator represents a promising advancement for subretinal prosthesis technology.