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Probiotics, the Immune Response and Acute Appendicitis: A Review

Carmine Petruzziello1, Angela Saviano2, Veronica Ojetti1,2,3

  • 1Emergency Department, Ospedale San Carlo di Nancy-GVM Care & Research, 00165 Rome, Italy.

Vaccines
|July 29, 2023
PubMed

Insights

Probiotics show promise as an add-on treatment for acute appendicitis, potentially improving patient health. Further research is needed to understand their role in the immunological response and long-term benefits.

Area of Science:

  • Gastroenterology
  • Immunology
  • Microbiology

Background:

  • Acute appendicitis is a frequent cause of emergency department visits, particularly affecting younger populations.
  • Appendectomy has been the standard treatment, but non-surgical options are emerging for uncomplicated cases.
  • Emerging research explores probiotics as a complementary therapy for acute appendicitis.

Purpose of the Study:

  • To review clinical studies on probiotics in acute appendicitis.
  • To analyze the impact of probiotics on the immunological response.
  • To discuss limitations and future research directions.

Main Methods:

  • Systematic review of clinical trials.
  • Analysis of immunological markers and patient outcomes.
  • Synthesis of existing literature on probiotic adjunctive therapy.

Main Results:

  • Preliminary studies suggest potential health benefits of probiotics.
  • Probiotics may modulate the immune response in acute appendicitis.
  • Evidence is still developing, requiring further investigation.

Conclusions:

  • Probiotics represent a potential adjunctive therapy for acute appendicitis.
  • Further research is necessary to confirm efficacy and optimal use.
  • Understanding the immunological mechanisms is key for future applications.

Keywords:
acute appendicitisbifidobacteriaemergency departmentgutimmune systemlactobacilliprobiotics

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