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Hepatitis Delta Virus-Host Protein Interactions: From Entry to Egress
Susannah Stephenson-Tsoris1, T Jake Liang1
1Liver Diseases Branch, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, MD 20892, USA.
Viruses
|July 29, 2023
Summary
Hepatitis delta virus (HDV), the most severe hepatitis cause, has poorly understood replication mechanisms. This review details host factors interacting with HDV throughout its replication cycle, informing potential therapies.
Area of Science:
- Virology
- Hepatology
- Molecular Biology
Background:
- Hepatitis delta virus (HDV) is the smallest human virus.
- HDV infection causes the most severe form of viral hepatitis.
- HDV replication and host interactions remain incompletely understood.
Conclusions:
- Understanding HDV-host protein interactions is crucial for comprehending viral pathogenesis.
- Knowledge of these interactions provides a basis for novel therapeutic strategies against HDV.
- Further research into specific host factors may reveal new antiviral targets.
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