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Updated: Jul 20, 2025

Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain
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Isolation and Flow Cytometric Analysis of Immune Cells from the Ischemic Mouse Brain

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Stem Cells Attenuate the Inflammation Crosstalk Between Ischemic Stroke and Multiple Sclerosis: A Review

Molly Monsour1, Jonah Gordon1, Gavin Lockard1

  • 1Morsani College of Medicine, University of South Florida, Tampa, FL, USA.

Cell Transplantation
|July 29, 2023
PubMed

Insights

Multiple sclerosis (MS) increases ischemic stroke (IS) risk due to overlapping inflammation. Cell-based regenerative medicine may reduce IS incidence by improving neurovascular unit function in MS patients.

Area of Science:

  • Neuroscience
  • Immunology
  • Regenerative Medicine

Background:

  • Multiple sclerosis (MS) involves significant neuroinflammation.
  • This inflammation creates conditions conducive to ischemic stroke (IS) development.
  • Ischemic stroke is a severe complication in MS patients, worsening neurovascular unit (NVU) impairment.

Purpose of the Study:

  • To review evidence supporting cell-based regenerative medicine for MS.
  • To explore its potential in mitigating IS risk in MS patients.
  • To address the lack of therapies targeting IS incidence in MS.

Main Methods:

  • Review of preclinical and clinical evidence.
  • Analysis of the interplay between MS-induced inflammation and IS pathology.
  • Evaluation of NVU dysfunction and its role in disease progression.

Main Results:

  • Neuroinflammation in MS significantly elevates IS risk.
  • Shared inflammatory pathways exacerbate NVU damage in both conditions.
  • Current therapies do not specifically target IS reduction in MS.

Conclusions:

  • Cell-based regenerative medicine offers a promising therapeutic strategy.
  • Augmenting NVU function and reducing inflammation can ameliorate IS risk in MS.
  • This approach holds potential for improving outcomes for MS patients at risk of stroke.
Keywords:
ischemic strokemultiple sclerosisneuroinflammationstem cells

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