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Related Experiment Video

Updated: Jul 20, 2025

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

Published on: June 7, 2024

2-hydroxyglutarate rides the cancer-immunity cycle.

Iosifina P Foskolou¹, Lukas Bunse², Jan Van den Bossche³

¹Department of Hematopoiesis, Sanquin Research and Department of Hematology University Medical Center, University of Amsterdam, the Netherlands.

Current Opinion in Biotechnology

|July 29, 2023

Summary

Both D- and L-2-hydroxyglutarate (2HG) enantiomers impact immune cells in the tumor microenvironment. This review explores their roles, moving beyond D-2HG

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Area of Science:

Metabolism
Immunology
Oncology

Background:

2-hydroxyglutarate (2HG) is a Krebs cycle byproduct with D- and L- enantiomers.
Both enantiomers accumulate in cancer and immune cells, influencing cell function.
D-2HG was initially viewed as an oncometabolite but also regulates immune function.

Purpose of the Study:

To review the distinct roles of D- and L-2HG enantiomers.
To examine the impact of 2HG enantiomers on immune cells within the tumor microenvironment.

Main Methods:

Literature review of studies on 2HG enantiomers and immune cells.
Analysis of research on D-2HG and L-2HG in cancer and immunity.

Main Results:

D-2HG physiologically accumulates in immune cells, regulating immune function.
L-2HG acts as an immunometabolite in T cells and can be induced in cancers.
Both enantiomers influence immune cell behavior within the tumor microenvironment.

Conclusions:

2HG enantiomers have complex and distinct roles in cancer and immunity.
Understanding these roles is crucial for cancer immunology and therapeutic strategies.