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Lipoprotein(a) in clinical practice: A guide for the clinician

Chayakrit Krittanawong1, Neil Sagar Maitra2, Adham H El-Sherbini3

  • 1Cardiology Division, NYU Langone Health and NYU School of Medicine, New York, NY, United States of America.

Progress in Cardiovascular Diseases
|July 29, 2023
PubMed

Insights

Serum lipoprotein(a) (Lp(a)) is a key risk factor for cardiovascular disease (CVD). Emerging research explores Lp(a) genetics, mechanisms, and new therapies to lower Lp(a) and reduce CVD risk.

Area of Science:

  • Cardiology
  • Genetics
  • Biochemistry

Background:

  • Cardiovascular disease (CVD) is a leading global cause of mortality.
  • Serum lipoprotein(a) (Lp(a)) is an independent and causative risk factor for atherosclerotic CVD and calcific aortic valvular disease.

Purpose of the Study:

  • To review recent advances in understanding lipoprotein(a) (Lp(a)).
  • To discuss current management strategies and emerging therapies for Lp(a) reduction.
  • To explore future directions in targeting Lp(a) for CVD prevention.

Main Methods:

  • Review of recent scientific literature on Lp(a).
  • Analysis of genetic polymorphisms in the LPA gene.
  • Examination of real-world data on risk factor interactions.
  • Evaluation of metabolic pathway targets for Lp(a) lowering.

Main Results:

  • Novel insights into Lp(a) epidemiology and pathogenic mechanisms.
  • Identification of genetic factors influencing Lp(a) levels.
  • Understanding of Lp(a) interactions with other cardiovascular risk factors.
  • Emerging therapeutic targets for Lp(a) reduction.

Conclusions:

  • Lp(a) is a critical target for CVD risk reduction.
  • Advances in understanding Lp(a) pave the way for new treatment strategies.
  • Future research should focus on effective Lp(a)-lowering therapies.

Keywords:
AtherosclerosisCalcific aortic stenosisCoronary artery diseaseDyslipidemiaGeneticsLipoprotein(a)PathophysiologyRisk factors

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