Related Experiment Video
Updated: Jul 20, 2025

Reaggregate Thymus Cultures
Published on: August 28, 2008
Thymic mimicry: The art of imitation
Vanja Cabric1,2, Chrysothemis C Brown1,2,3
1Immuno-Oncology, Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Abstract:
Display of tissue self-antigens within the thymus is critical for the regulation of self-reactive T cells. In this issue of JEM, Michelson et al. (2023. J. Exp. Med.https://doi.org/10.1084/jem.20230461) continue to advance our understanding of self-antigen representation by medullary thymic epithelial cells, identifying a new role for Hnf4γ in the regulation of thymic mimetic cells as well as their peripheral counterparts.
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