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Updated: Jul 20, 2025

Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome ARDS
Published on: April 7, 2021
Three subtypes of postoperative ARDS that showing different outcomes and responses to mechanical ventilation and
Jianmin Ling1, Han Liu2, Dongge Yu1
1Department of Emergency Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.
Background:
ARDS is a heterogeneous clinical syndrome, and operation and trauma are common indirect etiologies. The identification of postoperative ARDS subtypes may optimize individualized clinical management.
Objectives:
To identify the subtypes of postoperative ARDS and explore the impact of therapy on outcomes.
Methods:
This retrospective study used data obtained from a database. Patients diagnosed with ARDS who underwent surgical procedures within 7 days were included in the study. Laboratory and clinical variables were used for latent profile analysis (LPA). XGBoost and multivariable logistic regression models were used to explore the association between therapy and outcomes.
Results:
A total of 1065 patients were included. The LPA identified three subtypes of postoperative ARDS: Patients in profile 1 were mainly accepted neurosurgery, while those in profile 2 and 3 were treated with orthopedic and vascular or thoracic surgery, respectively. The XGBoost model effectively predicted mortality with an AUC of 0.935, which was higher than SOFA (0.622), APACHE 2 (0.629), SLIP (0.579), and SLIP-2 (0.550).
Conclusions:
This study identified three subtypes of postoperative ARDS with different clinical characteristics, mechanical support, and fluid resuscitation responses.
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