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Related Concept Videos

Infertility in Males01:23

Infertility in Males

295
Male infertility affects millions of couples worldwide, arising from various factors that impact different stages of the reproductive process. An endocrine imbalance resulting from conditions like hypogonadism, Klinefelter syndrome, or pituitary disorders can disrupt hormone levels and reduce sperm production. Testicular defects, such as tumors, cryptorchidism, atrophic testes, abnormal sperm morphology, and low sperm count or motility, may arise due to genetic factors, structural...
295

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Successful cryptozoospermia management with multiple semen specimen collection.

Jessica A Marinaro1, Aaron Brant1, Caroline Kang2

  • 1Department of Urology, Weill Cornell Medicine, New York, New York.

Fertility and Sterility
|July 30, 2023
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Summary
This summary is machine-generated.

Nearly 10% of men with azoospermia can avoid microdissection testicular sperm extraction (mTESE) by providing a fresh ejaculated sample for intracytoplasmic sperm injection (ICSI). Short abstinence periods may improve sperm motility for men with cryptozoospermia.

Keywords:
ARTAbstinencecryptozoospermiainfertilitysemen

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Area of Science:

  • Reproductive Medicine
  • Andrology
  • Infertility Treatment

Background:

  • Azoospermia, characterized by the absence of sperm in ejaculate, often necessitates surgical sperm retrieval like microdissection testicular sperm extraction (mTESE).
  • Intracytoplasmic sperm injection (ICSI) is a key assisted reproductive technology for overcoming male infertility.
  • Identifying viable sperm in ejaculates can potentially obviate the need for invasive surgical procedures.

Purpose of the Study:

  • To determine the prevalence of sperm suitable for ICSI in fresh ejaculated semen samples from men scheduled for mTESE.
  • To evaluate the impact of short abstinence periods on semen quality and ICSI outcomes in men with cryptozoospermia.

Main Methods:

  • Retrospective cohort study at an academic medical center.
  • Analysis of 727 men scheduled for mTESE between September 2015 and May 2021.
  • Assessment of ejaculated sperm presence for ICSI and semen parameters.

Main Results:

  • 9.5% of planned mTESE procedures were canceled due to the identification of ICSI-suitable sperm in pre-operative ejaculates.
  • 6.9% of men utilized these ejaculated sperm for ICSI, achieving a 36% live birth rate per attempt.
  • Shorter abstinence periods (<24 hours) were associated with improved sperm motility.

Conclusions:

  • Providing a fresh ejaculated sample on the day of mTESE can help nearly 10% of men with azoospermia avoid surgery, with satisfactory ICSI outcomes.
  • Multiple ejaculated samples over a short period do not negatively impact sperm concentration and may enhance motility in men with cryptozoospermia.