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In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
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Methionine restriction and antitumor immunity
Fangchao Wei1, Jason W Locasale1
1Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC 27710, USA.
Trends in Cancer
|July 30, 2023
Abstract:
Fang et al. recently reported in Cancer Cell that methionine restriction increases antitumor immunity by enhancing cyclic GMP-AMP synthase (cGAS) activity and promoting its dissociation from chromatin. This finding identifies a potential strategy to target cGAS demethylation in cancer therapy by altering methionine metabolism.
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