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Risk factors for mortality in pseudomonas aeruginosa bacteremia in children

Jian Chen1, Haixin Huang1, Chengjun Liu1

  • 1Department of Critical Care Medicine, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.

Pediatrics and Neonatology
|July 30, 2023
PubMed

Insights

Pseudomonas aeruginosa bacteremia in children is a serious hospital-acquired infection. Respiratory failure and liver impairment significantly increase the risk of 60-day mortality in these pediatric patients.

Area of Science:

  • Pediatric Infectious Diseases
  • Clinical Microbiology
  • Hospital Epidemiology

Background:

  • Pseudomonas aeruginosa (P. aeruginosa) bacteremia is a significant cause of gram-negative bacilli infections in children, ranking third to fourth in incidence.
  • It is a common opportunistic pathogen in hospital settings, posing a considerable threat to vulnerable pediatric populations.

Purpose of the Study:

  • To investigate the clinical characteristics of children diagnosed with P. aeruginosa bacteremia.
  • To identify independent risk factors associated with 60-day in-hospital mortality in this patient group.

Main Methods:

  • A retrospective study was conducted at a tertiary pediatric hospital from January 2015 to December 2021.
  • Kaplan-Meier survival analysis and logistic regression were employed to analyze time-to-event outcomes and risk factors for mortality.

Main Results:

  • Out of 75 pediatric patients with P. aeruginosa bacteremia, common underlying conditions included immunosuppression (52%), neutropenia (50.7%), and hematological malignancies (48%).
  • Significant complications observed were septic shock (33.3%), respiratory failure (40%), and liver function impairment (26.7%).
  • The 60-day in-hospital mortality rate was 17.3%. Independent risk factors for mortality were respiratory failure (OR 39.329) and liver function impairment (OR 17.925).

Conclusions:

  • Respiratory failure and liver function impairment are critical indicators of poor prognosis in pediatric P. aeruginosa bacteremia.
  • Early identification and management of these complications are crucial for improving survival rates in affected children.
Abstract

Keywords:
Pseudomonas aeruginosabacteremiachildrenmortality

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