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Normal Ventricular and Regional Blood Flow Volumes and Native T1 Values in Healthy Japanese Children Obtained from

Yuichi Ishikawa1, Hiroaki Urabe2, Yuya Yamada1

  • 1Department of Cardiology, Fukuoka Children's Hospital.

International Heart Journal
|July 30, 2023
PubMed

Insights

This study establishes normal reference ranges for cardiovascular magnetic resonance (CMR) imaging in children, providing crucial data for ventricular volumes, mass, blood flow, and T1 values in the pediatric population.

Area of Science:

  • Pediatric Cardiology
  • Cardiovascular Imaging
  • Biomedical Engineering

Background:

  • Establishing age-related reference ranges for cardiovascular magnetic resonance (CMR) parameters in children is critical for accurate diagnosis and management.
  • Existing data for pediatric ventricular volumes, mass, blood flow, and T1 values, particularly in infants and toddlers, are inconsistent.
  • Lack of standardized normal values hinders the reliable interpretation of CMR findings in pediatric cardiovascular diseases.

Purpose of the Study:

  • To determine and establish normal age-related reference values for comprehensive cardiovascular magnetic resonance (CMR) imaging in a pediatric cohort.
  • To provide reliable data for ventricular volumes, myocardial mass, regional blood flow, and T1 values in children.
  • To facilitate accurate assessment of cardiovascular health in the pediatric population using CMR.

Main Methods:

  • Comprehensive CMR imaging was performed on 23 healthy children aged 0.1 to 15.3 years.
  • Techniques included cine, 2-dimensional phase-contrast imaging, and native T1 mapping.
  • Measurements encompassed ventricular volumes, masses, 11 regional blood flow volumes, and myocardial and liver T1 values.

Main Results:

  • Excellent inter-rater agreement (>0.94 ICC) was observed for most CMR parameters, with good agreement for RV mass, myocardial, and liver T1 values.
  • Exponential relationships were found between body surface area (BSA) and ventricular volumes, mass, and regional blood flow (normal value = a*BSAb).
  • Age-dependent regression models were established for myocardial T1 values (linear with age) and hepatic T1 values (quadratic with age).

Conclusions:

  • This study successfully provides comprehensive normal reference values for pediatric CMR imaging in Japanese children.
  • The established regression models enable accurate age- and BSA-adjusted assessment of cardiovascular parameters.
  • These findings will aid in the standardized interpretation of CMR scans and improve the diagnosis of pediatric cardiovascular conditions.

Keywords:
2-dimensionalFlow volumeNormal heartPhase contrastT1 mapping

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