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Updated: Jul 20, 2025

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The Role of Mitochondrial Biogenesis in Ischemic Stroke

Behrouz Shademan1, Cigir Biray Avci1, Vahidreza Karamad1

  • 1Department of Medical Biology, Faculty of Medicine, Ege University, 35040 Izmir, Turkey.

Journal of Integrative Neuroscience
|July 31, 2023
PubMed

Insights

Mitochondria play a key role in brain cell death after ischemic stroke. Understanding mitochondrial function in stroke can lead to new treatments for this neurological disorder.

Area of Science:

  • Neuroscience
  • Cell Biology
  • Pathology

Background:

  • Ischemic stroke results from reduced blood flow to the brain, causing neuronal damage.
  • Common causes include large artery occlusion, embolism, small vessel disease, and hemodynamic factors.
  • Organelles, particularly mitochondria, are increasingly recognized for their role in cellular signaling and function during ischemia.

Purpose of the Study:

  • To explore the molecular mechanisms of mitochondria in cerebral ischemia.
  • To investigate the involvement of mitochondria in ischemia-induced neuronal death and protection.

Main Methods:

  • Review of current literature on mitochondrial involvement in cerebral ischemia.
  • Analysis of mitochondrial roles in reactive oxygen species generation/scavenging, apoptosis, biogenesis, dynamics, and inflammation.
  • Examination of electron transport chain dysfunction in ischemic conditions.

Main Results:

  • Mitochondria are implicated in generating and scavenging reactive oxygen species during cerebral ischemia.
  • Mitochondrial dysfunction affects apoptosis, biogenesis, dynamics, and inflammation pathways.
  • Electron transport chain dysfunction is a key component of mitochondrial involvement.

Conclusions:

  • Mitochondria are critical players in the pathophysiology of ischemic stroke.
  • Further understanding of mitochondrial mechanisms offers potential for novel therapeutic strategies.
  • Targeting mitochondrial pathways may enhance neuronal protection and improve stroke treatment outcomes.

Keywords:
electron transport chainischemic strokemitochondrial biogenesisneuronal death

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