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Updated: Jul 20, 2025

Improving Student Outcomes with an Adaptable Molecular Cloning Course-Based Undergraduate Research Experience
Published on: November 15, 2024
CoLab: A workshop-based undergraduate research experience for entering college students
Adrian Wierzchowski1, Donald J Wink1, Hongyang Zhang1
1Department of Chemistry, University of Illinois at Chicago, 4500 Science and Engineering South, 845 W. Taylor Street, Chicago, IL 60607.
The STEM CoLab Program uses course-based undergraduate research experiences (CUREs) to enhance early college chemistry students' knowledge and skills. This novel summer workshop successfully integrated in-vitro and in-silico research methods for remote learning.
Area of Science:
- Chemistry Education
- Biochemistry
- Computational Chemistry
Background:
- Traditional undergraduate chemistry labs often fail to meet educational goals for problem-solving and connecting macroscopic observations to submicroscopic phenomena.
- Course-Based Undergraduate Research Experiences (CUREs) and non-traditional summer workshops are emerging as effective pedagogical alternatives.
- There is a need for early-college programs that build foundational research and presentation skills.
Purpose of the Study:
- To describe the STEM CoLab Program, a novel summer workshop designed to enhance undergraduate chemistry students' research and presentation skills.
- To implement CUREs principles for incoming university students, focusing on foundational chemistry knowledge and laboratory techniques.
- To adapt the program for remote learning environments, incorporating both in-vitro and in-silico research components.
Main Methods:
- The STEM CoLab Program utilizes principles of CUREs for incoming freshmen.
- Students engaged in research on various chemical phenomena between 2016 and 2021.
- During 2020-2021, remote learning involved a take-home kit for in-vitro salivary amylase studies and in-silico computer-based visualizations of amylase-inhibitor interactions using PyMOL and docking tools.
Main Results:
- The program successfully provided early undergraduate students with research and presentation skill development.
- The adapted remote learning approach effectively integrated in-vitro and in-silico methodologies.
- Data from 2016-2021 demonstrate the program's sustained impact on student learning.
Conclusions:
- The STEM CoLab Program offers a successful model for integrating CUREs principles into early undergraduate chemistry education.
- The program's adaptability to remote learning, utilizing combined in-vitro and in-silico methods, provides a scalable and effective educational experience.
- This approach enhances students' ability to connect laboratory observations with molecular-level understanding and computational modeling.
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