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Related Experiment Video

Updated: Jul 20, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
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Is There a Predictable Cost-Benefit Ratio in Preeclampsia?

Dogukan Ozkan1, Betul Tokgoz Cakir1, Ceren Polat Kamaci1

  • 1Obstetrics and Gynaecology, Etlik Zübeyde Hanim EAH, Ankara, TUR.

Cureus
|July 31, 2023
PubMed
Summary

This study found that neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and aspartate aminotransferase-to-platelet ratio index (APRI) cannot predict preeclampsia (PE). These inflammatory markers lack clinical significance for assessing PE risk.

Keywords:
aspartate aminotransferase platelet ratio index (apri)gestational hypertensionneutrophil lymphocyte ratio (nlr)platelet lymphocyte ratio (plr)preeclampsiasevere preeclampsia

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Area of Science:

  • Obstetrics and Gynecology
  • Perinatal Medicine
  • Inflammatory Markers in Pregnancy

Background:

  • Preeclampsia (PE) affects 2-8% of pregnancies and is linked to systemic inflammatory response (SIR) markers.
  • Identifying predictive markers for PE is crucial for high-risk pregnancies.

Purpose of the Study:

  • To investigate the predictive role of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and aspartate aminotransferase-to-platelet ratio index (APRI) in preeclampsia.
  • To determine the clinical significance of these SIR markers in predicting PE development.

Main Methods:

  • A cohort of 300 pregnant women (151 with PE, 149 controls) was studied.
  • Blood samples were analyzed for NLR, PLR, and APRI at hospitalization.
  • Receiver operating characteristic (ROC) curve analysis was used to assess predictive capabilities.

Main Results:

  • No significant differences were observed in mean NLR, PLR, and APRI values between the PE and control groups.
  • ROC analysis indicated that none of these parameters could reliably predict preeclampsia.
  • Hypertensive individuals were hospitalized earlier, with significantly higher blood pressure.

Conclusions:

  • Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and APRI do not possess clinical significance for predicting preeclampsia.
  • These inflammatory markers are not useful in assessing the developmental risk of PE.